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» Authors » Krishna P Datla

Krishna P Datla

Explore the profile of Krishna P Datla including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 228
Followers 0
Related Specialties
Biochemistry
Neurology
Pharmacology
Top 10 Co-Authors
David T Dexter
Virginia Zbarsky
Martin J Croucher
Anthony C Vernon
Okezie I Aruoma
Shabnam Parkar
Hugh Chan
Alan Crozier
Amitabye Luximon-Ramma
Helen Paur
Published In
Neuroreport
Biofactors
Parkinsons Dis
Free Radic Res
J Neurochem
Affiliations
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Recent Articles
1.
Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease
Chan H, Paur H, Vernon A, Zabarsky V, Datla K, Croucher M, et al.
Parkinsons Dis . 2010 Oct; 2010. PMID: 20948891
Clinical trials have demonstrated positive proof of efficacy of dual metabotropic glutamate receptor 2/3 (mGluR2/3) agonists in both anxiety and schizophrenia. Importantly, evidence suggests that these drugs may also be...
2.
Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease
Datla K, Zbarsky V, Rai D, Parkar S, Osakabe N, Aruoma O, et al.
J Am Coll Nutr . 2007 Oct; 26(4):341-9. PMID: 17906186
Objective: Antioxidants from plants were known to reduce the oxidative stress by scavenging free radicals, chelating metal ions and reducing inflammation. As increased oxidative stress was implicated in the nigrostriatal...
3.
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo
Vernon A, Zbarsky V, Datla K, Croucher M, Dexter D
J Neurochem . 2007 Aug; 103(3):1075-91. PMID: 17714448
Evidence suggests that increased glutamatergic input to the substantia nigra pars compacta as a result of hyperactivity of subthalalmic nucleus output pathways may contribute to the progressive degeneration of nigral...
4.
Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions
Luximon-Ramma A, Neergheen V, Bahorun T, Crozier A, Zbarsky V, Datla K, et al.
Biofactors . 2006 Oct; 27(1-4):79-91. PMID: 17012766
There is increasing interest in the emerging view that tea improves the antioxidant status in vivo and thereby helps to lower risk of certain types of cancer, coronary heart disease...
5.
Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4-phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo
Vernon A, Zbarsky V, Datla K, Dexter D, Croucher M
J Pharmacol Exp Ther . 2006 Oct; 320(1):397-409. PMID: 17012606
Evidence from several studies suggests that the progressive degeneration of dopaminergic (DA) neurones of the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) may in part be due to...
6.
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
Zbarsky V, Datla K, Parkar S, Rai D, Aruoma O, Dexter D
Free Radic Res . 2005 Nov; 39(10):1119-25. PMID: 16298737
Although the cause of dopaminergic cell death in Parkinson's disease (PD) remains unknown, oxidative stress has been strongly implicated. Because of their ability to combat oxidative stress, diet derived phenolic...
7.
Differences in dopaminergic neuroprotective effects of estrogen during estrous cycle
Datla K, Murray H, Pillai A, Gillies G, Dexter D
Neuroreport . 2003 Jan; 14(1):47-50. PMID: 12544829
Previous studies suggest that estrogen treatment protects nigrostriatal dopaminergic neurons, but have not examined whether the changes in estrogen levels during estrous cycle can influence the susceptibility of these neurons...