Krishna B Sainis
Overview
Explore the profile of Krishna B Sainis including associated specialties, affiliations and a list of published articles.
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21
Citations
342
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Recent Articles
1.
Gupta P, Chakraborty P, Kumar S, Singh P, Rajan M, Sainis K, et al.
PLoS One
. 2016 May;
11(5):e0154725.
PMID: 27148868
Rapid emergence of drug resistance in Mycobacterium tuberculosis (MTB) is a major health concern and demands the development of novel adjunct immunotherapeutic agents capable of modulating the host immune responses...
2.
Suryavanshi S, Sharma D, Checker R, Thoh M, Gota V, Sandur S, et al.
Free Radic Biol Med
. 2015 Apr;
85:56-70.
PMID: 25872101
Hematopoietic stem cells and progenitor cells (HSPC) are low in abundance and exhibit high radiosensitivity and their ability to divide dramatically decreases following exposure to ionizing radiation. Our earlier studies...
3.
Singh R, Shankar B, Sainis K
Cell Signal
. 2014 Apr;
26(7):1604-15.
PMID: 24705025
Macrophages in the tumor microenvironment play an important role in tumor cell survival. They influence the tumor cell to proliferate, invade into surrounding normal tissues and metastasize to local and...
4.
Checker R, Patwardhan R, Sharma D, Menon J, Thoh M, Sandur S, et al.
Inflammation
. 2013 Nov;
37(2):542-54.
PMID: 24234154
Plumbagin has been reported to modulate cellular redox status and suppress NF-κB. In the present study, we investigated the effect of plumbagin on lipopolysaccharide (LPS)-induced endotoxic shock, oxidative stress and...
5.
Pal S, Shankar B, Sainis K
Cytokine
. 2013 Aug;
64(1):196-207.
PMID: 23972545
Cytokines in tumor microenvironment play an important role in the success or failure of molecular targeted therapies. We have chosen tumor necrosis factor α (TNF-α), TNF related apoptosis inducing ligand...
6.
Patwardhan R, Checker R, Sharma D, Sandur S, Sainis K
PLoS One
. 2013 Jun;
8(6):e65929.
PMID: 23776571
Prolonged oxidative stress favors tumorigenic environment and inflammation. Oxidative stress may trigger redox adaptation mechanism(s) in tumor cells but not normal cells. This may increase levels of intracellular antioxidants and...
7.
Pandey V, Shankar B, Sainis K
Int Immunopharmacol
. 2012 Oct;
14(4):641-9.
PMID: 23079132
The immunogenicity of dendritic cells (DC) is known to increase with their maturation state and both are induced by microbial products like LPS. In this study, we have investigated the...
8.
Checker R, Sandur S, Sharma D, Patwardhan R, Jayakumar S, Kohli V, et al.
PLoS One
. 2012 Feb;
7(2):e31318.
PMID: 22363615
Background: Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries, peppermint, rosemary, oregano and prunes and has been reported to...
9.
Checker R, Sharma D, Sandur S, Khan N, Patwardhan R, Kohli V, et al.
Free Radic Res
. 2011 Jun;
45(8):975-85.
PMID: 21651451
Recent investigations suggest that cellular redox status may play a key role in the regulation of several immune functions. Treatment of lymphocytes with vitamin K3 (menadione) resulted in a significant...
10.
Khan N, Sandur S, Checker R, Sharma D, Poduval T, Sainis K
Free Radic Biol Med
. 2011 May;
51(1):115-28.
PMID: 21530647
There are no reports describing the ability of pro-oxidants to protect against radiation-induced apoptosis. Activation of the redox-sensitive transcription factor Nrf2 by low levels of ROS is known to protect...