Kosuke Yamaguchi
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Explore the profile of Kosuke Yamaguchi including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
445
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Recent Articles
1.
Yanai M, Sakamoto T, Nonaka T, Nakada T, Matsuoka S, Moriyama S, et al.
Intern Med
. 2025 Feb;
PMID: 39924236
Currently, immune checkpoint inhibitors (ICIs) are the standard treatment for malignant pleural mesothelioma (MPM). The characteristic responses to ICI treatment include pseudoprogression (PP) and hyperprogressive disease (HPD), which require attention....
2.
Yanai M, Sakamoto T, Uetani N, Nonaka T, Nakada T, Matsuoka S, et al.
Intern Med
. 2025 Feb;
PMID: 39894491
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are highly effective against EGFR-mutant non-small-cell lung carcinoma but can cause serious adverse events, such as interstitial lung disease (ILD). Treatment...
3.
Harada T, Inui G, Takata M, Okazaki R, Yamaguchi K, Yamasaki A
Intern Med
. 2025 Jan;
PMID: 39814382
Asthma is characterized by chronic airway inflammation as its primary pathological condition, which leads to various respiratory symptoms due to airway narrowing, with type 2 inflammation playing a central role....
4.
Itakura M, Yamaguchi K, Uchida K
Biosci Biotechnol Biochem
. 2024 Dec;
89(2):187-192.
PMID: 39658000
We take a wide variety of antioxidants, including polyphenols, daily from our diet. They are generally considered to be beneficial for our health. However, the intrinsic function of antioxidants in...
5.
Fujiki J, Maeda N, Yamaguchi K, Ohtsuki Y, Iwano H
Mol Cell Endocrinol
. 2024 Aug;
593:112336.
PMID: 39094930
Steroidogenesis occurs locally in peripheral tissues and via adrenal and gonadal glands' biosynthesis. The C2C12 mouse myoblast cell line and rat skeletal muscles harbor a local steroidogenesis pathway for glucocorticoids,...
6.
Harada T, Uetani N, Inui G, Ishikawa H, Funaki Y, Takata M, et al.
Respir Med Case Rep
. 2024 May;
49:102035.
PMID: 38712312
Pembrolizumab is an anti-programmed cell death-1 (PD-1) antibody used to treat various cancer types. Treatments with such immune checkpoint inhibitors cause immune-related adverse events. However, airway inflammation caused by immune-related...
7.
Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, et al.
Nat Commun
. 2024 Apr;
15(1):2960.
PMID: 38580649
DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1 functions solely by stimulating DNA methylation maintenance...
8.
Anan Y, Itakura M, Shimoda T, Yamaguchi K, Lu P, Nagata K, et al.
Commun Biol
. 2024 Feb;
7(1):149.
PMID: 38310133
Anti-DNA antibodies (Abs), serological hallmarks of systemic lupus erythematosus (SLE) and markers for diagnosis and disease activity, show a specificity for non-nucleic acid molecules, such as N-pyrrolated proteins (pyrP) containing...
9.
Yakhou L, Azogui A, Gupta N, Richard Albert J, Miura F, Ferry L, et al.
Nucleic Acids Res
. 2023 Aug;
51(19):10292-10308.
PMID: 37650637
Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements and higher-order chromatin structures. Consequently, these chromatin marks are...
10.
Gupta N, Yakhou L, Richard Albert J, Azogui A, Ferry L, Kirsh O, et al.
Nat Struct Mol Biol
. 2023 Jul;
30(8):1105-1118.
PMID: 37488355
In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse '2-cell-like cells' (2CLCs), which appear at low frequency in...