Kolin M Clark
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Explore the profile of Kolin M Clark including associated specialties, affiliations and a list of published articles.
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6
Citations
93
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Recent Articles
1.
Wang Q, Clark K, Tiwari R, Raju N, Tharp G, Rogers J, et al.
Cell
. 2024 Mar;
187(5):1223-1237.e16.
PMID: 38428396
While CD4 T cell depletion is key to disease progression in people living with HIV and SIV-infected macaques, the mechanisms underlying this depletion remain incompletely understood, with most cell death...
2.
Clark K, Wang Q, Shan L
Methods Mol Biol
. 2023 Apr;
2641:67-79.
PMID: 37074642
The pattern recognition receptor CARD8 is an inflammasome sensor for intracellular HIV-1 protease activity. Previously, the only method for studying the CARD8 inflammasome has been through utilizing DPP8/DPP9 inhibitors including...
3.
Clark K, Pal P, Kim J, Wang Q, Shan L
Adv Immunol
. 2023 Apr;
157:59-100.
PMID: 37061288
The biggest challenge to immune control of HIV infection is the rapid within-host viral evolution, which allows selection of viral variants that escape from T cell and antibody recognition. Thus,...
4.
Li Y, Gao H, Clark K, Shan L
JCI Insight
. 2023 Feb;
8(7).
PMID: 36821374
HIV-1 usually utilizes CCR5 as its coreceptor and rarely switches to a CXCR4-tropic virus until the late stage of infection. CCR5+CD4+ T cells are the major virus-producing cells in viremic...
5.
Clark K, Kim J, Wang Q, Gao H, Presti R, Shan L
Nat Chem Biol
. 2022 Nov;
19(4):431-439.
PMID: 36357533
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) induce pyroptosis of HIV-1-infected CD4 T cells through induction of intracellular HIV-1 protease activity, which activates the CARD8 inflammasome. Because high concentrations of NNRTIs are...
6.
Wang Q, Gao H, Clark K, Mugisha C, Davis K, Tang J, et al.
Science
. 2021 Feb;
371(6535).
PMID: 33542150
HIV-1 has high mutation rates and exists as mutant swarms within the host. Rapid evolution of HIV-1 allows the virus to outpace the host immune system, leading to viral persistence....