Koji Umezawa
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Explore the profile of Koji Umezawa including associated specialties, affiliations and a list of published articles.
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Articles
44
Citations
233
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Recent Articles
1.
Ikeda R, Kimura C, Nihashi Y, Umezawa K, Shimosato T, Takaya T
Life (Basel)
. 2025 Jan;
14(12.
PMID: 39768281
A CpG oligodeoxynucleotide (CpG-ODN), iSN40, was originally identified as promoting the mineralization and differentiation of osteoblasts, independent of Toll-like receptor 9 (TLR9). Since CpG ODNs are often recognized by TLR9...
2.
Umezawa K, Ikeda R, Sakamoto T, Enomoto Y, Nihashi Y, Shinji S, et al.
BioTech (Basel)
. 2024 May;
13(2).
PMID: 38804293
A myogenetic oligodeoxynucleotide (myoDN), iSN04 (5'-AGA TTA GGG TGA GGG TGA-3'), is a single-stranded 18-base telomeric DNA that serves as an anti-nucleolin aptamer and induces myogenic differentiation, which is expected...
3.
Yokomine M, Morimoto J, Fukuda Y, Ueda T, Takeuchi K, Umezawa K, et al.
Chem Sci
. 2024 May;
15(19):7051-7060.
PMID: 38756815
Peptoids are a promising drug modality targeting disease-related proteins, but how a peptoid engages in protein binding is poorly understood. This is primarily due to a lack of high-resolution peptoid-protein...
4.
Aoyama M, Kimura N, Yamakawa M, Suzuki S, Umezawa K, Kii I
Biochem Biophys Res Commun
. 2023 Nov;
688:149220.
PMID: 37952278
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is one of the drug target kinases involved in neurological disorders. DYRK1A phosphorylates substrate proteins related to disease progression in an intermolecular manner. Meanwhile,...
5.
Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762684
An 18-base myogenetic oligodeoxynucleotide (myoDN), iSN04, acts as an anti-nucleolin aptamer and induces myogenic differentiation of skeletal muscle myoblasts. This study investigated the effect of iSN04 on murine embryonic stem...
6.
Kurihara K, Umezawa K, Donnelly A, Sperling B, Liao G, Hecht M, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2218281120.
PMID: 37695900
Producing novel enzymes that are catalytically active in vitro and biologically functional in vivo is a key goal of synthetic biology. Previously, we reported Syn-F4, the first de novo protein...
7.
Watanabe S, Haruyama R, Umezawa K, Tomioka I, Nakamura S, Katayama S, et al.
J Nutr Biochem
. 2023 Aug;
121:109433.
PMID: 37648097
A decrease in the NAD level in adipocytes causes adipose-tissue dysfunction, leading to systemic glucose, and lipid metabolism failure. Therefore, it is necessary to develop small molecules and nutraceuticals that...
8.
Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S
Int Immunopharmacol
. 2022 Dec;
115:109617.
PMID: 36566519
Excessive activation of CD4 T cells increases cytokine production substantially and induces immune-mediated diseases. Procyanidins are polyphenols with anti-inflammatory properties. Procyanidin B2 (PCB2) gallate [specifically, PCB2 3,3''-di-O-gallate (PCB2DG)] inhibits cytokine...
9.
Kim J, Kobayashi H, Yokomine M, Shiratori Y, Ueda T, Takeuchi K, et al.
Org Biomol Chem
. 2022 Aug;
20(35):6994-7000.
PMID: 35993969
-Substituted peptides, such as peptoids and β-peptoids, have been reported to have unique structures with diverse functions, like catalysis and manipulation of biomolecular functions. Recently, the preorganization of monomer shape...
10.
Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T
Nanomaterials (Basel)
. 2022 May;
12(10).
PMID: 35630904
Dysfunction of bone-forming cells, osteoblasts, is one of the causes of osteoporosis. Accumulating evidence has indicated that oligodeoxynucleotides (ODNs) designed from genome sequences have the potential to regulate osteogenic cell...