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Koichi Kokame

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Articles 116
Citations 2558
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Recent Articles
1.
Kokame K
Blood Adv . 2025 Feb; PMID: 39903133
No abstract available.
2.
Maruyama K, Kokame K
J Thromb Haemost . 2024 Sep; 22(12):3510-3520. PMID: 39243859
Background: Protein S (PS) is an anticoagulant that functions as a cofactor for activated protein C and the tissue factor pathway inhibitor. PS deficiency is a risk factor for venous...
3.
Takiguchi H, Miura M, Shirai S, Soga Y, Hanyu M, Sakaguchi G, et al.
Res Pract Thromb Haemost . 2024 Jun; 8(4):102431. PMID: 38840664
Background: Various cardiovascular diseases cause acquired von Willebrand syndrome (AVWS), which is characterized by a decrease in high-molecular-weight (large) von Willebrand factor (VWF) multimers. Mitral regurgitation (MR) has been reported...
4.
Yoshino T, Kuriyama T, Utsumi S, Shimakawa T, Minami M, Hayashi M, et al.
Rinsho Ketsueki . 2024 Apr; 65(3):142-146. PMID: 38569856
A 27-year-old woman was diagnosed with idiopathic thrombocytopenic purpura in the neonatal period, and was admitted to our hospital after presenting with impaired consciousness, purpura, nausea and vomiting, with a...
5.
Okubo N, Sugawara S, Fujiwara T, Sakatsume K, Doman T, Yamashita M, et al.
Res Pract Thromb Haemost . 2024 Jan; 8(1):102284. PMID: 38268521
Background: Severe aortic stenosis (AS) causes acquired von Willebrand syndrome by the excessive shear stress-dependent cleavage of high molecular weight multimers of von Willebrand factor (VWF). While the current standard...
6.
Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, et al.
Int J Hematol . 2023 Sep; 118(5):529-546. PMID: 37689812
Thrombotic thrombocytopenic purpura (TTP) can rapidly become a life-threatening condition, and the importance of its appropriate diagnosis and treatment cannot be overstated. Until recently, TTP has mainly been diagnosed by...
7.
8.
Akiyama M, Eura Y, Kokame K
Thromb Res . 2022 Sep; 219:49-59. PMID: 36116391
Background: The plasma metalloprotease ADAMTS13 regulates the thrombotic activity of the von Willebrand factor (VWF). ADAMTS13 is highly glycosylated and its carbohydrate chains are capped with sialic acid (SA). Thus,...
9.
Tsuji A, Miyata T, Sekine A, Neki R, Kokame K, Tomita T, et al.
Intern Med . 2022 Aug; 62(6):885-888. PMID: 35945029
Antithrombin resistance (ATR) is a newly identified strong genetic predisposition to venous thromboembolism (VTE) caused by genetic variations in prothrombin with substitutions of Arg at position 596 with either Leu,...
10.
Fukuma K, Yamagami H, Ihara M, Tanaka T, Miyata T, Miyata S, et al.
J Atheroscler Thromb . 2022 Mar; 30(1):39-55. PMID: 35249906
Aims: We aimed to determine the association between acute platelet reactivity and clinical outcome in acute ischemic stroke (AIS) or transient ischemic attack (TIA) with large-artery atherosclerosis (LAA). Methods: In...