Koen van de Wetering
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Explore the profile of Koen van de Wetering including associated specialties, affiliations and a list of published articles.
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52
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1683
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Recent Articles
1.
Ottone O, Mundo J, Kwakye B, Slaweski A, Collins J, Wu Q, et al.
Aging Cell
. 2025 Feb;
:e14504.
PMID: 39930949
Despite the high prevalence of age-dependent intervertebral disc calcification, there is a glaring lack of treatment options for this debilitating pathology. We investigated the efficacy of long-term oral KCitrate supplementation...
2.
Reichenberger E, OBrien K, Hatori A, Carpenter T, van de Wetering K, Flaman L, et al.
JBMR Plus
. 2024 Aug;
8(9):ziae103.
PMID: 39165910
Craniometaphyseal dysplasia (CMD) is a rare genetic bone disorder, characterized by progressive thickening of craniofacial bones and flared metaphyses of long bones. Craniofacial hyperostosis leads to the obstruction of neural...
3.
Ottone O, Mundo J, Kwakye B, Slaweski A, Collins J, Wu Q, et al.
bioRxiv
. 2024 Jul;
PMID: 39071393
Despite the high prevalence of age-dependent intervertebral disc calcification, there is a glaring lack of treatment options for this debilitating pathology. Here, we investigate the efficacy of long-term oral KCitrate...
4.
Novais E, Narayanan R, Canseco J, van de Wetering K, Kepler C, Hilibrand A, et al.
Bone Res
. 2024 Jan;
12(1):3.
PMID: 38253615
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis, ectopic calcification,...
5.
Ohnishi T, Tran V, Sao K, Ramteke P, Querido W, Barve R, et al.
Cell Death Dis
. 2023 Jul;
14(7):447.
PMID: 37468461
Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine triphosphate efflux transporter, progressive ankylosis (ANK) is a...
6.
Lundkvist S, Niaziorimi F, Szeri F, Caffet M, Terry S, Johansson G, et al.
Anal Bioanal Chem
. 2022 Nov;
415(3):481-492.
PMID: 36400967
Inorganic pyrophosphate (PPi) is a crucial extracellular mineralization regulator. Low plasma PPi concentrations underlie the soft tissue calcification present in several rare hereditary mineralization disorders as well as in more...
7.
Szeri F, Miko A, Navasiolava N, Kaposi A, Verschuere S, Molnar B, et al.
Hum Mutat
. 2022 Nov;
43(12):1872-1881.
PMID: 36317459
ABCC6 promotes ATP efflux from hepatocytes to bloodstream. ATP is metabolized to pyrophosphate, an inhibitor of ectopic calcification. Pathogenic variants of ABCC6 cause pseudoxanthoma elasticum, a highly variable recessive ectopic...
8.
Li V, He Y, Contrepois K, Liu H, Kim J, Wiggenhorn A, et al.
Nature
. 2022 Jun;
606(7915):785-790.
PMID: 35705806
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear. Here we...
9.
Boneski P, Madhu V, Tomlinson R, Shapiro I, van de Wetering K, Risbud M
Front Cell Dev Biol
. 2022 Feb;
10:823249.
PMID: 35186933
Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging...
10.
Ralph D, van de Wetering K, Uitto J, Li Q
Am J Pathol
. 2022 Feb;
192(5):762-770.
PMID: 35182493
Pathologic soft tissue calcification can occur in both genetic and acquired clinical conditions, causing significant morbidity and mortality. Although the pathomechanisms of pathologic calcification are poorly understood, major progress has...