Koelina Ganguly
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Explore the profile of Koelina Ganguly including associated specialties, affiliations and a list of published articles.
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24
Citations
377
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Recent Articles
1.
Shah A, Ganguly K, Rauth S, Sheree S, Khan I, Ganti A, et al.
Drug Resist Updat
. 2024 Sep;
77:101146.
PMID: 39243602
Despite the ongoing advances in interventional strategies (surgery, chemotherapy, radiotherapy, and immunotherapy) for managing pancreatic ductal adenocarcinoma (PDAC), the development of therapy refractory phenotypes remains a significant challenge. Resistance to...
2.
Atri P, Shah A, Natarajan G, Rachagani S, Rauth S, Ganguly K, et al.
NPJ Precis Oncol
. 2024 Mar;
8(1):66.
PMID: 38454151
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-world PC...
3.
Renzi F, Seamann A, Ganguly K, Pandey K, Byrareddy S, Batra S, et al.
ACS Pharmacol Transl Sci
. 2023 Jun;
6(6):857-867.
PMID: 37325447
Entry inhibitors are an important resource in the response against emerging pathogens like the novel SARS-CoV-2, which enters human cells via interaction between the surface spike glycoprotein and the cellular...
4.
Ganguly K, Kimmelman A
Trends Cancer
. 2023 Mar;
9(6):461-471.
PMID: 36935322
Cancer is a systemic disease that involves malignant cell-intrinsic and -extrinsic metabolic adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities in the primary tumor microenvironment, leaving...
5.
Rauth S, Ganguly K, Atri P, Parte S, Nimmakayala R, Varadharaj V, et al.
Cell Rep
. 2023 Jan;
42(2):112043.
PMID: 36709426
Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as...
6.
Bhatia R, Siddiqui J, Ganguly K, Thompson C, Cannon A, Aithal A, et al.
Oncogene
. 2023 Jan;
42(10):759-770.
PMID: 36624189
Mucin4 (MUC4) appears early during pancreatic intraepithelial neoplasia-1 (PanIN1), coinciding with the expression of epidermal growth factor receptor-1 (EGFR). The EGFR signaling is required for the onset of Kras-driven pancreatic...
7.
Bhatia R, Thompson C, Clement E, Ganguly K, Cox J, Rauth S, et al.
Gastroenterology
. 2022 Jul;
163(4):1064-1078.e10.
PMID: 35788346
Background & Aims: Epidemiological studies have established alcohol and smoking as independent risk factors for recurrent acute pancreatitis and chronic pancreatitis. However, the molecular players responsible for the progressive loss...
8.
Ganguly K, Shah A, Atri P, Rauth S, Ponnusamy M, Kumar S, et al.
Semin Cancer Biol
. 2022 Mar;
86(Pt 2):511-520.
PMID: 35346803
Pancreatic cancer (PC) is exemplified by a complex immune-suppressive, fibrotic tumor microenvironment (TME), and aberrant expression of mucins. The constant crosstalk between cancer cells, cancer-associated fibroblasts (CAFs), and the immune...
9.
Ganguly K, Cox J, Ghersi D, Grandgenett P, Hollingsworth M, Jain M, et al.
Gastroenterology
. 2022 Feb;
162(7):2032-2046.e12.
PMID: 35219699
Background & Aims: Secreted mucin 5AC (MUC5AC) promotes pancreatic cancer (PC) progression and chemoresistance, suggesting its clinical association with poor prognosis. RNA sequencing analysis from the autochthonous pancreatic tumors showed...
10.
Rauth S, Karmakar S, Shah A, Seshacharyulu P, Nimmakayala R, Ganguly K, et al.
Mol Cell Biol
. 2021 Sep;
41(12):e0013521.
PMID: 34570619
RNA polymerase II-associated factor 1 (PAF1)/pancreatic differentiation 2 (PD2) is a core subunit of the human PAF1 complex (PAF1C) that regulates the RNA polymerase II function during transcriptional elongation. PAF1/PD2...