Knud H Nierhaus
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Explore the profile of Knud H Nierhaus including associated specialties, affiliations and a list of published articles.
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81
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2614
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Recent Articles
1.
Tamaru D, Amikura K, Shimizu Y, Nierhaus K, Ueda T
RNA
. 2018 Aug;
24(11):1512-1519.
PMID: 30076205
Reconstitution of ribosomes in vitro from individual ribosomal proteins provides a powerful tool for understanding the ribosome assembly process including the sequential incorporation of ribosomal proteins. However, conventional assembly methods...
2.
Nikolay R, Hilal T, Qin B, Mielke T, Burger J, Loerke J, et al.
Mol Cell
. 2018 Jun;
70(5):881-893.e3.
PMID: 29883607
The assembly of ribosomal subunits is an essential prerequisite for protein biosynthesis in all domains of life. Although biochemical and biophysical approaches have advanced our understanding of ribosome assembly, our...
3.
Wruck F, Katranidis A, Nierhaus K, Buldt G, Hegner M
Proc Natl Acad Sci U S A
. 2017 May;
114(22):E4399-E4407.
PMID: 28507157
Protein biosynthesis is inherently coupled to cotranslational protein folding. Folding of the nascent chain already occurs during synthesis and is mediated by spatial constraints imposed by the ribosomal exit tunnel...
4.
Qin B, Yamamoto H, Ueda T, Varshney U, Nierhaus K
J Mol Biol
. 2016 Jun;
428(18):3577-87.
PMID: 27261258
It is general wisdom that termination of bacterial protein synthesis is obligatorily followed by recycling governed by the factors ribosomal recycling factor (RRF), EF-G, and IF3, where the ribosome dissociates...
5.
Nikolay R, Schmidt S, Schlomer R, Deuerling E, Nierhaus K
Antibiotics (Basel)
. 2016 May;
5(2).
PMID: 27240412
Many antibiotics target the ribosome and interfere with its translation cycle. Since translation is the source of all cellular proteins including ribosomal proteins, protein synthesis and ribosome assembly are interdependent....
6.
70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria
Yamamoto H, Wittek D, Gupta R, Qin B, Ueda T, Krause R, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(9):E1180-9.
PMID: 26888283
According to the standard model of bacterial translation initiation, the small ribosomal 30S subunit binds to the initiation site of an mRNA with the help of three initiation factors (IF1-IF3)....
7.
8.
Achenbach J, Jahnz M, Bethge L, Paal K, Jung M, Schuster M, et al.
Nucleic Acids Res
. 2015 May;
43(12):5687-98.
PMID: 26026160
Key components of the translational apparatus, i.e. ribosomes, elongation factor EF-Tu and most aminoacyl-tRNA synthetases, are stereoselective and prevent incorporation of d-amino acids (d-aa) into polypeptides. The rare appearance of...
9.
Achenbach J, Nierhaus K
Biochimie
. 2014 Dec;
114:80-9.
PMID: 25514765
The ribosome translates the sequence of codons of an mRNA into the corresponding sequence of amino acids as it moves along the mRNA with a codon-step width of about 10...
10.
Akabane S, Ueda T, Nierhaus K, Takeuchi N
PLoS Genet
. 2014 Sep;
10(9):e1004616.
PMID: 25233460
Release factors (RFs) govern the termination phase of protein synthesis. Human mitochondria harbor four different members of the class 1 RF family: RF1Lmt/mtRF1a, RF1mt, C12orf65 and ICT1. The homolog of...