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Klaus Pfeffer

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Articles 197
Citations 10071
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Recent Articles
1.
Kravets E, Poschmann G, Hansch S, Raba V, Weidtkamp-Peters S, Degrandi D, et al.
PLoS One . 2025 Jan; 20(1):e0316209. PMID: 39854420
Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasma gondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous...
2.
Scharf S, Friedrichs L, Bock R, Borrelli M, MacKenzie C, Pfeffer K, et al.
Microorganisms . 2024 Nov; 12(11). PMID: 39597681
(1) Background: Microbial keratitis is a serious eye infection that carries a significant risk of vision loss. spp. are known to cause keratitis and their bacterial endosymbionts can increase virulence...
3.
Rembe J, Garabet W, Lackmann J, Alizadehrahrouei S, Augustin M, Dissemond J, et al.
Biomedicines . 2024 Oct; 12(10). PMID: 39457500
Patient-specific diagnostic and therapeutic approaches are important in the care of people with chronic wounds. The heterogeneity of underlying disease profiles and the diversity of the wound micro-environment make generalized...
4.
Fuchs S, Hulse L, Tamayo T, Kolbe-Busch S, Pfeffer K, Dilthey A
mSystems . 2024 Oct; 9(11):e0108024. PMID: 39373471
Importance: Genomic surveillance involves sequencing the genomes and measuring the relatedness of bacteria from different patients or locations in the same healthcare facility, enabling an improved understanding of pathogen transmission...
5.
Mazzone F, Hoeppner A, Reiners J, Gertzen C, Applegate V, Abdullaziz M, et al.
Biochem J . 2024 Aug; 481(16):1075-1096. PMID: 39105673
Toxoplasma gondii is a widely distributed apicomplexan parasite causing toxoplasmosis, a critical health issue for immunocompromised individuals and for congenitally infected foetuses. Current treatment options are limited in number and...
6.
Mazzone F, Klischan M, Greb J, Smits S, Pietruszka J, Pfeffer K
Front Chem . 2024 Aug; 12:1406307. PMID: 39104777
Toxoplasmosis is a zoonotic disease caused by , an apicomplexan parasite that infects approximately a third of the world's human population. This disease can cause serious complications during pregnancy and...
7.
Moellmann H, Kommer K, Karnatz N, Pfeffer K, Henrich B, Rana M
J Clin Med . 2024 Jul; 13(14). PMID: 39064142
: In oral and maxillofacial surgery, the reconstruction of defects often involves the transfer of skin tissue into the oral cavity utilizing microvascular grafts. This study investigates postoperative changes in...
8.
Abdullaziz M, Takada S, Illarionov B, Pessanha de Carvalho L, Sakamoto Y, Hofmann S, et al.
ACS Infect Dis . 2024 Apr; 10(5):1739-1752. PMID: 38647213
Reverse analogs of the phosphonohydroxamic acid antibiotic fosmidomycin are potent inhibitors of the nonmevalonate isoprenoid biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR, IspC) of . Some novel analogs with large phenylalkyl...
9.
Spohr P, Scharf S, Rommerskirchen A, Henrich B, Jager P, Klau G, et al.
Sci Rep . 2024 Feb; 14(1):4068. PMID: 38374282
The gut microbiome is a diverse ecosystem, dominated by bacteria; however, fungi, phages/viruses, archaea, and protozoa are also important members of the gut microbiota. Exploration of taxonomic compositions beyond bacteria...
10.
El-Kashef D, Obidake D, Schiedlauske K, Deipenbrock A, Scharf S, Wang H, et al.
Mar Drugs . 2024 Jan; 22(1). PMID: 38276643
A new prenylated indole diketopiperazine alkaloid, rubrumline P (), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, , collected at...