Klaus J Stark
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Explore the profile of Klaus J Stark including associated specialties, affiliations and a list of published articles.
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36
Citations
972
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Recent Articles
1.
Gorski M, Wiegrebe S, Burkhardt R, Behr M, Kuchenhoff H, Stark K, et al.
Sci Rep
. 2025 Jan;
15(1):3540.
PMID: 39875408
Loss of kidney function is a substantial personal and public health burden. Kidney function is typically assessed as estimated glomerular filtration rate (eGFR) based on serum creatinine. UK Biobank provides...
2.
Winkler T, Wiegrebe S, Herold J, Stark K, Kuchenhoff H, Heid I
Genome Biol
. 2024 Nov;
25(1):300.
PMID: 39609904
Background: Genome-wide association studies (GWAS) have identified thousands of loci for disease-related human traits in cross-sectional data. However, the impact of age on genetic effects is underacknowledged. Also, identifying genetic...
3.
Wiegrebe S, Gorski M, Herold J, Stark K, Thorand B, Gieger C, et al.
Nat Commun
. 2024 Nov;
15(1):10061.
PMID: 39567532
Understanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We...
4.
Drewitz K, Stark K, Zimmermann M, Heid I, Apfelbacher C
Dermatology
. 2024 Sep;
241(1):1-9.
PMID: 39342937
Introduction: Atopic dermatitis (AD) and psoriasis appear to affect 2-3% (lifetime prevalence) people worldwide. However, there are little epidemiological data on the prevalence of those two chronic inflammatory skin diseases...
5.
Herold J, Wiegrebe S, Nano J, Jung B, Gorski M, Thorand B, et al.
Kidney Int
. 2024 Jul;
106(4):699-711.
PMID: 39084259
Understanding normal aging of kidney function is pivotal to help distinguish individuals at particular risk for chronic kidney disease. Glomerular filtration rate (GFR) is typically estimated via serum creatinine (eGFRcrea)...
6.
Koller A, Filosi M, Weissensteiner H, Fazzini F, Gorski M, Pattaro C, et al.
Sci Rep
. 2024 Jan;
14(1):2083.
PMID: 38267512
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association studies (GWAS) have been performed to unravel underlying mechanisms of mtDNA-CN regulation....
7.
Scholz M, Horn K, Pott J, Wuttke M, Kuhnapfel A, Nasr M, et al.
Nat Commun
. 2024 Jan;
15(1):586.
PMID: 38233393
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n ...
8.
Koller A, Lamina C, Brandl C, Zimmermann M, Stark K, Weissensteiner H, et al.
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003595
Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased levels of reactive oxygen species lead to damaged...
9.
Stanzick K, Stark K, Gorski M, Schodel J, Kruger R, Kronenberg F, et al.
BMC Bioinformatics
. 2023 Sep;
24(1):355.
PMID: 37735349
Background: Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent association signals...
10.
Herold J, Zimmermann M, Gorski M, Gunther F, Weber B, Helbig H, et al.
Invest Ophthalmol Vis Sci
. 2023 Sep;
64(12):31.
PMID: 37721739
Purpose: The purpose of this study was to evaluate the utility of combining the Clinical Classification (CC) and the Three Continent age-related macular degeneration (AMD) Consortium Severity Scale (3CACSS) for...