Klaus-Heinrich Rohm
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Explore the profile of Klaus-Heinrich Rohm including associated specialties, affiliations and a list of published articles.
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14
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239
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Recent Articles
1.
Mann T, Scherner C, Rohm K, Kolbe L
Int J Mol Sci
. 2018 Mar;
19(3).
PMID: 29495618
Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compounds described in the literature lack clinical efficiency due to insufficient inhibitory activity...
2.
Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, et al.
J Invest Dermatol
. 2018 Feb;
138(7):1601-1608.
PMID: 29427586
Tyrosinase is the rate-limiting enzyme of melanin production and, accordingly, is the most prominent target for inhibiting hyperpigmentation. Numerous tyrosinase inhibitors have been identified, but most of those lack clinical...
3.
Verma S, Mehta R, Maiti P, Rohm K, Sonawane A
Biochim Biophys Acta
. 2014 Apr;
1844(7):1219-30.
PMID: 24721562
Bacterial asparaginases (EC 3.5.1.1) have attracted considerable attention because enzymes of this group are used in the therapy of certain forms of leukemia. Class II asparaginase from Escherichia coli (EcA),...
4.
Sun W, Wendt M, Klebe G, Rohm K
J Enzyme Inhib Med Chem
. 2013 Jan;
29(1):92-9.
PMID: 23323989
Abstract Tyrosinases (monophenol monooxygenases, EC 1.14.18.1) utilize a reaction mechanism that involves two intertwined catalytic cycles and at least three different ligand-binding enzyme forms. Therefore a variety of different inhibition...
5.
Cordes P, Sun W, Wolber R, Kolbe L, Klebe G, Rohm K
Biol Chem
. 2012 Dec;
394(5):685-93.
PMID: 23241670
Mammalian tyrosinases are key enzymes of melanin formation. Their native forms undergo complex maturation and sorting processes before being integrated into the melanosomal membrane, which greatly complicates their heterologous expression...
6.
Singh B, Rohm K
Microbiology (Reading)
. 2008 Mar;
154(Pt 3):797-809.
PMID: 18310026
We describe an ATP-binding cassette (ABC) transporter in Pseudomonas putida KT2440 that mediates the uptake of glutamate and aspartate. The system (AatJMQP, for acidic amino acid transport) is encoded by...
7.
Lindner H, Tafler-Naumann M, Rohm K
Biochimie
. 2008 Jan;
90(5):773-80.
PMID: 18222180
Mammalian aminoacylase-1 (Acy1) participates in the breakdown of N-acetylated amino acids during intracellular protein catabolism. Acy1 is most abundantly expressed in the kidney tubular epithelium. Lately, Acy1 deficiency was identified...
8.
Singh B, Rohm K
Biol Chem
. 2007 Dec;
389(1):33-6.
PMID: 18095867
The specificity of bacterial nutrient importers of the ATP-binding cassette (ABC) type depends on external receptor proteins that not only bind the solute to be transported, but also initiate the...
9.
Sonawane A, Singh B, Rohm K
Appl Environ Microbiol
. 2006 Oct;
72(10):6569-77.
PMID: 17021207
Pseudomonas putida KT2440 metabolizes a wide range of carbon and nitrogen sources, including many amino acids. In this study, a sigma54-dependent two-component system that controls the uptake and metabolism of...
10.
Benjwal S, Verma S, Rohm K, Gursky O
Protein Sci
. 2006 Feb;
15(3):635-9.
PMID: 16452626
Thermal unfolding monitored by spectroscopy or calorimetry is widely used to determine protein stability. Equilibrium thermodynamic analysis of such unfolding is often hampered by its irreversibility, which usually results from...