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Kirill Chaprov

Explore the profile of Kirill Chaprov including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 34
Followers 0
Related Specialties
Biomedical Engineering
Biochemistry
Molecular Biology
Top 10 Co-Authors
Vasily Vorobyov
Alexander Deev
Natalia Ninkina
Viktor S Kokhan
Vladimir L Buchman
Yulia Aleksandrova
Margarita Neganova
Anna Gorlova
Tatyana Strekalova
Tamara A Ivanova
Published In
Biomedicines
Int J Mol Sci
CNS Neurosci Ther
Life Sci Space Res (Amst)
J Biol Chem
Affiliations
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Recent Articles
1.
Combined irradiation by gamma-rays and carbon-12 nuclei caused hyperlocomotion and change in striatal metabolism of rats
Kokhan V, Chaprov K, Abaimov D, Nesterov M, Pikalov V
Life Sci Space Res (Amst) . 2025 Jan; 44():99-107. PMID: 39864919
Exposure to ionizing radiation during manned deep space missions to Mars could lead to functional impairments of the central nervous system, which may compromise the success of the mission and...
2.
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors
Cespuglio R, Gorlova A, Zabegalov K, Chaprov K, Svirin E, Sitdikova K, et al.
Front Biosci (Landmark Ed) . 2025 Jan; 30(1):26778. PMID: 39862090
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions....
3.
Combined Ionizing Radiation Exposure by Gamma Rays and Carbon-12 Nuclei Increases Neurotrophic Factor Content and Prevents Age-Associated Decreases in the Volume of the Sensorimotor Cortex in Rats
Kokhan V, Pikalov V, Chaprov K, Gulyaev M
Int J Mol Sci . 2024 Jun; 25(12). PMID: 38928431
In orbital and ground-based experiments, it has been demonstrated that ionizing radiation (IR) can stimulate the locomotor and exploratory activity of rodents, but the underlying mechanism of this phenomenon remains...
4.
Disruption of Electroencephalogram Coherence between Cortex/Striatum and Midbrain Dopaminergic Regions in the Knock-Out Mice with Combined Loss of Alpha, Beta, and Gamma Synucleins
Vorobyov V, Deev A, Chaprov K, Ninkina N
Biomedicines . 2024 Apr; 12(4). PMID: 38672235
Methods: EEG data from seven groups of knock-out (KO) mice with combined deletions of alpha, beta, and gamma synucleins versus a group of wild-type (WT) mice were compared. EEG coherence...
5.
Early Effects of Alpha-Synuclein Depletion by Pan-Neuronal Inactivation of Encoding Gene on Electroencephalogram Coherence between Different Brain Regions in Mice
Vorobyov V, Deev A, Morozova O, Oganesyan Z, Krayushkina A, Ivanova T, et al.
Biomedicines . 2023 Dec; 11(12). PMID: 38137503
Methods: We analyzed electroencephalogram (EEG) coherence ("functional connectivity") between the cortex (MC), putamen (Pt), and dopamine-producing brain regions (ventral tegmental area, VTA, and substantia nigra, SN) in two groups of...
6.
Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS)
Trofimov A, Pavlov D, Goswami A, Gorlova A, Chaprov K, Umriukhin A, et al.
Brain Behav Immun Health . 2023 Sep; 33:100686. PMID: 37767237
CNS inflammation, including microglial activation, in response to peripheral infections are known to contribute to the pathology of both familial and sporadic neurodegenerative disease. The relationship between Fused-in-Sarcoma Protein (FUS)-mediated...
7.
Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids
Aleksandrova Y, Munkuev A, Mozhaitsev E, Suslov E, Tsypyshev D, Chaprov K, et al.
Int J Mol Sci . 2023 Jun; 24(11). PMID: 37298694
Novel monoterpene-based hydroxamic acids of two structural types were synthesized for the first time. The first type consisted of compounds with a hydroxamate group directly bound to acyclic, monocyclic and...
8.
Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis
Vorobyov V, Deev A, Chaprov K, Ustyugov A, Lysikova E
Biomedicines . 2023 May; 11(4). PMID: 37189768
Methods: In 5xFAD mice of 6-, 9-, 12-, and 18-month ages and their wild-type (WT) littermates, we analyzed baseline EEG coherence between the cortex, hippocampus/putamen, ventral tegmental area, and substantia...
9.
Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson's Disease Model by Alleviating Mitochondrial Dysfunction
Aleksandrova Y, Chaprov K, Podturkina A, Ardashov O, Yandulova E, Volcho K, et al.
Int J Mol Sci . 2023 Mar; 24(6). PMID: 36982914
Parkinson's disease is the second most common neurodegenerative disease. Unfortunately, there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian potential of trans-epoxide (1S,2S,3R,4S,6R)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo [4.1.0]heptan-2,3-diol (E-diol) was analyzed...
10.
Loss of the Synuclein Family Members Differentially Affects Baseline- and Apomorphine-Associated EEG Determinants in Single-, Double- and Triple-Knockout Mice
Vorobyov V, Deev A, Sukhanova I, Morozova O, Oganesyan Z, Chaprov K, et al.
Biomedicines . 2022 Dec; 10(12). PMID: 36551884
Synucleins comprise a family of small proteins highly expressed in the nervous system of vertebrates and involved in various intraneuronal processes. The malfunction of alpha-synuclein is one of the key...