Kiran Chaudhari
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Explore the profile of Kiran Chaudhari including associated specialties, affiliations and a list of published articles.
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23
Citations
226
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Recent Articles
1.
Liu R, Berry R, Wang L, Chaudhari K, Winters A, Sun Y, et al.
Transl Stroke Res
. 2024 Mar;
PMID: 38488999
Clinical studies have identified widespread white matter degeneration in ischemic stroke patients. However, contemporary research in stroke has predominately focused on the infarct and periinfarct penumbra regions. The involvement of...
2.
Yang S, Sun Y, Berry R, Choudhury G, Winters A, Chaudhari K, et al.
Aging Dis
. 2024 Feb;
15(6):2742-2751.
PMID: 38377020
Glutamate-mediated excitotoxicity has been extensively explored as a therapeutic target for the development of potential treatments of neurological disorders including stroke. However, the effect of glutamate on astrocytes under pathological...
3.
Chaudhari K, Gohar A, Claerhout S, Ganorkar R
ACS Omega
. 2023 Mar;
8(11):10411-10418.
PMID: 36969464
Controlling the isomeric impurity in a key raw material is always critical to achieve the corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. Clarithromycin 9-()-oxime is the...
4.
Sun Y, Winters A, Wang L, Chaudhari K, Berry R, Tang C, et al.
Life (Basel)
. 2023 Jan;
13(1).
PMID: 36676133
Astrocytes play critical roles in regulating neuronal synaptogenesis, maintaining blood-brain barrier integrity, and recycling neurotransmitters. Increasing numbers of studies have suggested astrocyte heterogeneity in morphology, gene profile, and function. However,...
5.
Wang L, Chaudhari K, Winters A, Sun Y, Berry R, Tang C, et al.
Transl Stroke Res
. 2022 Jul;
14(5):740-751.
PMID: 35867329
Transient ischemic attack (TIA) presents a high risk for subsequent stroke, Alzheimer's disease (AD), and related dementia (ADRD). However, the neuropathophysiology of TIA has been rarely studied. By evaluating recurrent...
6.
Xie D, Chen F, Zhang Y, Shi B, Song J, Chaudhari K, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(14):e2122217119.
PMID: 35344434
SignificanceA clear mechanistic understanding of metformin's antidiabetic effects is lacking. This is because suprapharmacological concentrations of metformin have been used in most studies. Using mouse models and human primary hepatocytes,...
7.
Wang L, Chaudhari K, Winters A, Sun Y, Liu R, Yang S
J Cereb Blood Flow Metab
. 2022 Jan;
42(7):1259-1271.
PMID: 35078350
The brain is highly complex with diverse structural characteristics in accordance with specific functions. Accordingly, differences in regional function, cellular compositions, and active metabolic pathways may link to differences in...
8.
Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease
Chaudhari K, Wang L, Kruse J, Winters A, Sumien N, Shetty R, et al.
Neurol Res
. 2021 Mar;
43(7):570-581.
PMID: 33688799
Background: The cerebellum's involvement in AD has been under-appreciated by historically labeling as a normal control in AD research. Methods: We determined the involvement of the cerebellum in AD progression....
9.
Chaudhari K, Wong J, Vann P, Como T, OBryant S, Sumien N
Antioxidants (Basel)
. 2020 Jul;
9(6).
PMID: 32630431
This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer's disease risk. Starting at 12...
10.
Chaudhari K, Wang J, Xu Y, Winters A, Wang L, Dong X, et al.
PLoS One
. 2020 Jun;
15(6):e0234571.
PMID: 32525922
Metformin, an anti-diabetes drug, has been recently emerging as a potential "anti-aging" intervention based on its reported beneficial actions against aging in preclinical studies. Nonetheless, very few metformin studies using...