Kira G Slepchenko
Overview
Explore the profile of Kira G Slepchenko including associated specialties, affiliations and a list of published articles.
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13
Citations
176
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Recent Articles
1.
Endogenous tau released from human cultures by neuronal activity is phosphorylated at multiple sites
Sindi G, Ismael S, Uddin R, Slepchenko K, Colvin R, Lee D
bioRxiv
. 2024 Jun;
PMID: 38854111
Tau is an intracellular protein but also known to be released into the extracellular fluid. Tau release mechanisms have drawn intense attention as these are known to play a key...
2.
Slepchenko K, Chen S, Corbin K, Colvin R, Nunemaker C
Metallomics
. 2023 Feb;
15(2).
PMID: 36737500
Synchrotron X-ray fluorescence microscopy (SXRF) presents a valuable opportunity to study the metallome of single cells because it simultaneously provides high-resolution subcellular distribution and quantitative cellular content of multiple elements....
3.
Slepchenko K, Chen S, Counts G, Corbin K, Colvin R, Nunemaker C
Metallomics
. 2021 Aug;
13(9).
PMID: 34402906
Pancreatic beta-cells synthesize and secrete insulin maintaining an organism's energy homeostasis. In humans, beta-cell dysfunction and death contribute to the pathogenesis of type 2 diabetes (T2D). Although the causes of...
4.
Duran-Ortiz S, Corbin K, Jahan I, Whitticar N, Morris S, Bartholomew A, et al.
Am J Physiol Endocrinol Metab
. 2021 May;
320(6):E1158-E1172.
PMID: 33938235
In the endocrine pancreas, growth hormone (GH) is known to promote pancreatic islet growth and insulin secretion. In this study, we show that GH receptor (GHR) loss in the germline...
5.
Slepchenko K, Corbin K, Nunemaker C
J Endocrinol
. 2019 Mar;
PMID: 30870813
Glucose-stimulated insulin secretion (GSIS) is a well-accepted method to investigate the physiological and pathophysiological function of islets. However, there is little consensus about which method is best for normalizing and...
6.
Slepchenko K, Holub J, Li Y
Cell Signal
. 2018 Feb;
44:148-157.
PMID: 29414441
Protein kinase C delta (PKCδ) is a Ser/Thr-specific kinase involved in many fundamental cellular processes including growth, differentiation and apoptosis. PKCδ is expressed ubiquitously in all known cell types, and...
7.
Slepchenko K, Lu Q, Li Y
Am J Physiol Cell Physiol
. 2017 Jul;
313(4):C448-C459.
PMID: 28747335
Both zinc (Zn) and reactive oxygen species (ROS) have been shown to accumulate during hypoxic-ischemic stress and play important roles in pathological processes. To understand the cross talk between the...
8.
Slepchenko K, Lu Q, Li Y
Int J Physiol Pathophysiol Pharmacol
. 2016 May;
8(1):44-51.
PMID: 27186322
Mitochondrial reactive oxygen species (ROS) are known to accumulate during chemical hypoxia, causing adverse effects on cell function and survival. Recent studies show important role zinc accumulation plays in dysfunction...
9.
Lu Q, Haragopal H, Slepchenko K, Stork C, Li Y
Int J Physiol Pathophysiol Pharmacol
. 2016 May;
8(1):35-43.
PMID: 27186321
Zinc (Zn(2+)) is required for numerous cellular functions. As such, the homeostasis and distribution of intracellular zinc can influence cellular metabolism and signaling. However, the exact distribution of free zinc...
10.
Slepchenko K, Daniels N, Guo A, Li Y
Endocrine
. 2015 Mar;
50(1):110-22.
PMID: 25771886
It is well known that zinc (Zn(2+)) is required for the process of insulin biosynthesis and the maturation of insulin secretory granules in pancreatic beta (β)-cells, and that changes in...