Kin Man Suen
Overview
Explore the profile of Kin Man Suen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
168
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Recent Articles
1.
Jones C, Rohwedder A, Suen K, Mohajerani S, Calabrese A, Knipp S, et al.
Heliyon
. 2024 Aug;
10(15):e35480.
PMID: 39165974
Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent...
2.
Lin C, Suen K, Lidster J, Ladbury J
Trends Cell Biol
. 2023 Sep;
34(5):371-379.
PMID: 37777392
Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of...
3.
Navarro I, Suen K, Bensaddek D, Tanpure A, Lamond A, Balasubramanian S, et al.
Wellcome Open Res
. 2023 Jul;
7():282.
PMID: 37475875
Methylation of carbon-5 of cytosines (m C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm C),...
4.
Lin C, Wieteska L, Poncet-Montange G, Suen K, Arold S, Ahmed Z, et al.
Commun Biol
. 2023 Jul;
6(1):728.
PMID: 37452126
Receptor tyrosine kinases (RTKs) are typically activated through a precise sequence of intracellular phosphorylation events starting with a tyrosine residue on the activation loop (A-loop) of the kinase domain (KD)....
5.
Stainthorp A, Lin C, Wang D, Medhi R, Ahmed Z, Suen K, et al.
Sci Rep
. 2023 Jun;
13(1):9784.
PMID: 37328606
Protein interactions with the microRNA (miRNA)-mediated gene silencing protein Argonaute 2 (AGO2) control miRNA expression. miRNA biogenesis starts with the production of precursor transcripts and culminates with the loading of...
6.
Ladbury J, Lin C, Suen K
Trends Biochem Sci
. 2023 Feb;
48(5):428-436.
PMID: 36759237
The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular outcome is low because of the promiscuous nature of signalling, the randomness of molecular diffusion through the...
7.
Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
Lin C, Suen K, Jeffrey P, Wieteska L, Lidster J, Bao P, et al.
Mol Cell
. 2022 Mar;
82(6):1089-1106.e12.
PMID: 35231400
The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to produce rapid, high-fidelity downstream response is exposed to the ambiguity of random diffusion to the target site. Liquid-liquid...
8.
Lin C, Wieteska L, Suen K, Kalverda A, Ahmed Z, Ladbury J
Commun Biol
. 2021 Apr;
4(1):437.
PMID: 33795832
The regulation of phosphatase activity is fundamental to the control of intracellular signalling and in particular the tyrosine kinase-mediated mitogen-activated protein kinase (MAPK) pathway. Shp2 is a ubiquitously expressed protein...
9.
Suen K, Braukmann F, Butler R, Bensaddek D, Akay A, Lin C, et al.
Nat Commun
. 2020 Aug;
11(1):4242.
PMID: 32843637
Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how...
10.
Lin C, Suen K, Stainthorp A, Wieteska L, Biggs G, Leitao A, et al.
Cancer Lett
. 2019 May;
457:86-97.
PMID: 31100409
Receptor tyrosine kinase (RTK)-mediated hyperactivation of the MAPK/Erk pathway is responsible for a large number of pathogenic outcomes including many cancers. Considerable effort has been directed at targeting this pathway...