Kimito Hirai
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Explore the profile of Kimito Hirai including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
144
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Recent Articles
1.
Ueda A, Shinoda-Ito Y, Takeuchi-Hatanaka K, Ito T, Ono S, Hirai K, et al.
BMC Oral Health
. 2025 Feb;
25(1):199.
PMID: 39923078
Backgrounds: Safe dental treatments that prevent nosocomial and cross-infections are essential for patients and dental workers. However, dental students sometimes pay inadequate attention to infection control, especially in preclinical practice,...
2.
Andrada A, Azuma M, Furusho H, Hirai K, Xu S, White R, et al.
J Endod
. 2020 Aug;
46(11):1648-1654.
PMID: 32763436
Introduction: The purpose of the present study was to compare the immunomodulatory effect of azithromycin (AZM), ampicillin (AMP), amoxicillin (AMX), and clindamycin (CLI) in vitro and AZM on preexisting periapical...
3.
Hirai K, Yamaguchi-Tomikawa T, Eguchi T, Maeda H, Takashiba S
Front Immunol
. 2020 Jun;
11:1017.
PMID: 32582160
Chronic periodontitis is an inflammatory disease caused by the formation of oral microbial biofilms. Periodontitis is associated with general health and not only oral diseases. is a well-known keystone pathogen...
4.
Nakagawa S, Omori K, Nakayama M, Mandai H, Yamamoto S, Kobayashi H, et al.
Int Immunopharmacol
. 2020 Mar;
83:106429.
PMID: 32222639
Pathophysiological bone resorption is commonly associated with periodontal disease and involves the excessive resorption of bone matrix by activated osteoclasts. Receptor activator of nuclear factor (NF)-κB ligand (RANKL) signaling pathways...
5.
Ito Y, Ito T, Yamashiro K, Mineshiba F, Hirai K, Omori K, et al.
Odontology
. 2019 Sep;
108(1):57-65.
PMID: 31520265
Dental caries is a type of oral microbiome dysbiosis and biofilm infection that affects oral and systemic conditions. For healthy life expectancy, natural bacteriostatic products are ideal for daily and...
6.
Sasaki H, Furusho H, Rider D, Dobeck J, Kuo W, Fujimura A, et al.
J Endod
. 2019 Feb;
45(2):181-188.
PMID: 30711175
Introduction: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but...
7.
Hirai K, Furusho H, Hirota K, Sasaki H
Int J Oral Sci
. 2018 Apr;
10(2):12.
PMID: 29654284
Hypoxia (low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on...
8.
Martins C, Sasaki H, Hirai K, Andrada A, Gomes-Filho J
Braz Oral Res
. 2016 Oct;
30(1):e78.
PMID: 27737351
The aim of this study was to compare potential aspects of periapical lesion formation in hypertensive and normotensive conditions using hypertensive (BPH/2J) and wild-type control (BPN/3J) mice. The mandibular first...
9.
Rider D, Furusho H, Xu S, Trachtenberg A, Kuo W, Hirai K, et al.
Anat Rec (Hoboken)
. 2016 Jun;
299(9):1281-92.
PMID: 27314637
Apical periodontitis (periapical lesions) is an infection-induced chronic inflammation in the jaw, ultimately resulting in the destruction of apical periodontal tissue. Toll-like receptors (TLRs) are prominent in the initial recognition...
10.
Sasaki H, Hirai K, Martins C, Furusho H, Battaglino R, Hashimoto K
Curr Pharm Des
. 2016 Feb;
22(15):2204-15.
PMID: 26881444
Background: Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and...