Khong-Loon Tiong
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Explore the profile of Khong-Loon Tiong including associated specialties, affiliations and a list of published articles.
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7
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38
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Recent Articles
1.
Assessing transcriptomic heterogeneity of single-cell RNASeq data by bulk-level gene expression data
Tiong K, Luzhbin D, Yeang C
BMC Bioinformatics
. 2024 Jun;
25(1):209.
PMID: 38867193
Background: Single-cell RNA sequencing (sc-RNASeq) data illuminate transcriptomic heterogeneity but also possess a high level of noise, abundant missing entries and sometimes inadequate or no cell type annotations at all....
2.
Tiong K, Sintupisut N, Lin M, Cheng C, Woolston A, Lin C, et al.
PLOS Digit Health
. 2023 Feb;
1(12):e0000151.
PMID: 36812605
Cancer cells harbor molecular alterations at all levels of information processing. Genomic/epigenomic and transcriptomic alterations are inter-related between genes, within and across cancer types and may affect clinical phenotypes. Despite...
3.
Tiong K, Lin Y, Yeang C
Biol Open
. 2022 Jun;
11(6).
PMID: 35665803
Despite the remarkable progress in probing tumor transcriptomic heterogeneity by single-cell RNA sequencing (sc-RNAseq) data, several gaps exist in prior studies. Tumor heterogeneity is frequently mentioned but not quantified. Clustering...
4.
Padakanti S, Tiong K, Chen Y, Yeang C
Sci Rep
. 2021 Sep;
11(1):17741.
PMID: 34493766
Principal Component Analysis (PCA) projects high-dimensional genotype data into a few components that discern populations. Ancestry Informative Markers (AIMs) are a small subset of SNPs capable of distinguishing populations. We...
5.
Tiong K, Yeang C
BMC Bioinformatics
. 2019 Mar;
20(1):145.
PMID: 30885118
Background: Gene Set Enrichment Analysis (GSEA) is a powerful tool to identify enriched functional categories of informative biomarkers. Canonical GSEA takes one-dimensional feature scores derived from the data of one...
6.
Tiong K, Yeang C
Sci Rep
. 2018 Aug;
8(1):11456.
PMID: 30061703
Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To...
7.
Tiong K, Chang K, Yeh K, Liu T, Wu J, Hsieh P, et al.
Neoplasia
. 2014 Jun;
16(5):441-50.
PMID: 24947187
Two genes are called synthetic lethal (SL) if their simultaneous mutations lead to cell death, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill...