Kherim Willems
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Explore the profile of Kherim Willems including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
233
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0
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Recent Articles
1.
Fatemi N, Taher A, Fondu J, Zhang L, De Moor T, Willems K, et al.
Lab Chip
. 2024 Aug;
24(18):4371-4378.
PMID: 39148372
Applications such as nucleic acid synthesis or next-generation sequencing involve repeated fluidic cycles with the same set of reagents. The large dead volumes present in external valves and pumps with...
2.
Voorspoels A, Gevers J, Santermans S, Akkan N, Martens K, Willems K, et al.
J Phys Chem A
. 2024 May;
128(19):3926-3933.
PMID: 38712508
Nanopore field-effect transistor (NP-FET) devices hold great promise as sensitive single-molecule sensors, which provide CMOS-based on-chip readout and are also highly amenable to parallelization. A plethora of applications will therefore...
3.
Lucas F, Willems K, Tadema M, Tych K, Maglia G, Wloka C
ACS Omega
. 2022 Aug;
7(30):26040-26046.
PMID: 35936408
Single-molecule nanopore electrophysiology is an emerging technique for the detection of analytes in aqueous solutions with high sensitivity. These detectors have proven applicable for the enzyme-assisted sequencing of oligonucleotides. There...
4.
Huang G, Voorspoels A, Abraham Versloot R, van der Heide N, Carlon E, Willems K, et al.
Angew Chem Int Ed Engl
. 2022 Jun;
61(34):e202206227.
PMID: 35759385
The real-time identification of protein biomarkers is crucial for the development of point-of-care and portable devices. Here, we use a PlyAB biological nanopore to detect haemoglobin (Hb) variants. Adult haemoglobin...
5.
Hoyer M, Crevenna A, Kitel R, Willems K, Czub M, Dubin G, et al.
Sci Rep
. 2022 Mar;
12(1):4682.
PMID: 35304498
Protein assembly plays an important role throughout all phyla of life, both physiologically and pathologically. In particular, aggregation and polymerization of proteins are key-strategies that regulate cellular function. In recent...
6.
Bayoumi M, Nomidis S, Willems K, Carlon E, Maglia G
Nano Lett
. 2020 Dec;
21(1):762-768.
PMID: 33342212
We present a synthetic nanoscale piston that uses chemical energy to perform molecular transport against an applied bias. Such a device comprises a 13 by 5 nm protein cylinder, embedded...
7.
Willems K, Ruic D, Lucas F, Barman U, Verellen N, Hofkens J, et al.
Nanoscale
. 2020 Aug;
12(32):16775-16795.
PMID: 32780087
Despite the broad success of biological nanopores as powerful instruments for the analysis of proteins and nucleic acids at the single-molecule level, a fast simulation methodology to accurately model their...
8.
Huang G, Willems K, Bartelds M, Van Dorpe P, Soskine M, Maglia G
Nano Lett
. 2020 Apr;
20(5):3819-3827.
PMID: 32271587
Biological nanopores are emerging as powerful tools for single-molecule analysis and sequencing. Here, we engineered the two-component pleurotolysin (PlyAB) toxin to assemble into 7.2 × 10.5 nm cylindrical nanopores with...
9.
Willems K, Ruic D, Biesemans A, Galenkamp N, Van Dorpe P, Maglia G
ACS Nano
. 2019 Aug;
13(9):9980-9992.
PMID: 31403770
The ability to confine and to study single molecules has enabled important advances in natural and applied sciences. Recently, we have shown that unlabeled proteins can be confined inside the...
10.
Chen C, Li Y, Kerman S, Neutens P, Willems K, Cornelissen S, et al.
Nat Commun
. 2018 May;
9(1):1733.
PMID: 29712902
Solid-state nanopores promise a scalable platform for single-molecule DNA analysis. Direct, real-time identification of nucleobases in DNA strands is still limited by the sensitivity and the spatial resolution of established...