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» Authors » Khawaja Ashfaque Ahmed

Khawaja Ashfaque Ahmed

Explore the profile of Khawaja Ashfaque Ahmed including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 43
Citations 478
Followers 0
Related Specialties
Veterinary Medicine
Allergy & Immunology
Science
Top 10 Co-Authors
Susantha Gomis
Shelly Popowich
Jim Xiang
Suresh K Tikoo
Lisanework E Ayalew
Philip Willson
Thushari Gunawardana
Ashish Gupta
Shanika Kurukulasuriya
Betty Chow-Lockerbie
Published In
Sci Rep
Vaccine
Avian Dis
Cell Mol Immunol
J Leukoc Biol
Affiliations
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Recent Articles
1.
Protection of Broiler Chickens Against Necrotic Enteritis by Intrapulmonary Delivery of a Live Clostridium perfringens Vaccine Exploiting the Gut-Lung-Axis Concept
Gautam H, Ahmed K, Subhasinghe I, Popowich S, Matsuyama-Kato A, Chow-Lockerbie B, et al.
Avian Dis . 2024 Oct; 68(3):240-253. PMID: 39400219
(CP)-induced necrotic enteritis (NE) is an economically important disease in the broiler chicken industry. The incidence of NE is common in 3-to-6-wk-old broiler chickens, once maternal antibodies start declining. Developing...
2.
Induction of trained immunity in broiler chickens following delivery of oligodeoxynucleotide containing CpG motifs to protect against Escherichia coli septicemia
Subhasinghe I, Ahmed K, Ayalew L, Gautam H, Popowich S, Matsuyama-Kato A, et al.
Sci Rep . 2024 Aug; 14(1):18882. PMID: 39143261
Oligodeoxynucleotides containing CpG motifs (CpG-ODN) can promote antimicrobial immunity in chickens by enriching immune compartments and activating immune cells. Innate memory, or trained immunity, has been demonstrated in humans and...
3.
Oligodeoxynucleotides containing CpG motifs upregulate bactericidal activities of heterophils and enhance immunoprotection of neonatal broiler chickens against Salmonella Typhimurium septicemia
Subhasinghe I, Matsuyama-Kato A, Ahmed K, Ayalew L, Gautam H, Popowich S, et al.
Poult Sci . 2024 Aug; 103(10):104078. PMID: 39096829
In the past, we demonstrated that oligodeoxynucleotides containing CpG motifs (CpG-ODN) mimicking bacterial DNA, stimulate the innate immune system of neonatal broiler chickens and protect them against Escherichia coli and...
4.
Exploring the predictive power of jejunal microbiome composition in clinical and subclinical necrotic enteritis caused by Clostridium perfringens: insights from a broiler chicken model
Gautam H, Ayalew L, Shaik N, Subhasinghe I, Popowich S, Chow-Lockerbie B, et al.
J Transl Med . 2024 Jan; 22(1):80. PMID: 38243294
Background: Necrotic enteritis (NE) is a severe intestinal infection that affects both humans and poultry. It is caused by the bacterium Clostridium perfringens (CP), but the precise mechanisms underlying the...
5.
Development of a multivalent adjuvanted inactivated vaccine against variant arthrotropic avian reoviruses
Ayalew L, Popowich S, Chow-Lockerbie B, Gautam H, Subhasinghe I, Ahmed K, et al.
Front Vet Sci . 2023 Nov; 10:1209597. PMID: 37920329
Variant avian reoviruses (ARVs) are economically important emerging pathogens of poultry, which mainly affect young broiler chickens and cause significant production losses. Currently, there are no effective commercial vaccines available...
6.
The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1 Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation
Ara A, Wu Z, Xu A, Ahmed K, Leary S, Islam M, et al.
Int J Mol Sci . 2022 Sep; 23(17). PMID: 36076931
Two common γ-chain family cytokines IL-2 and IL-15 stimulate the same mammalian target of rapamycin complex-1 (mTORC1) signaling yet induce effector T (T) and memory T (T) cell differentiation via...
7.
Evaluation of five circulating strains of variant infectious bursal disease virus (varIBDV) for their immunogenicity as broiler breeder vaccines and protective efficacy in neonatal broiler chicks
Kurukulasuriya S, Ahmed K, Ojkic D, Gunawardana T, Goonewardene K, Gupta A, et al.
Vaccine . 2022 Aug; 40(38):5608-5614. PMID: 36008236
The majority of infectious bursal disease virus (IBDV) strains circulating in the broiler chicken industry in Canada are variant strains (varIBDV). Despite high levels of maternally derived antibodies (MtAb), the...
8.
Exposure of embryonating eggs to Enterococcus faecalis and Escherichia coli potentiates E. coli pathogenicity and increases mortality of neonatal chickens
Karunarathna R, Ahmed K, Goonewardene K, Gunawardana T, Kurukulasuriya S, Liu M, et al.
Poult Sci . 2022 Jul; 101(8):101983. PMID: 35793601
Enterococci and Escherichia coli are opportunistic pathogens of poultry and are associated with embryo and neonatal chick mortality. We have recently demonstrated that 56% of dead broiler chicken embryos in...
9.
Comparison of Therapeutic Antibiotics, Probiotics, and Synthetic CpG-ODNs for Protective Efficacy Against Lethal Infection and Impact on the Immune System in Neonatal Broiler Chickens
Gunawardana T, Ahmed K, Popowich S, Kurukulasuriya S, Lockerbie B, Karunarathana R, et al.
Avian Dis . 2022 Jun; 66(2):165-175. PMID: 35723931
The poultry industry needs alternatives to antibiotics, as there are growing public concerns about the emergence of antimicrobial resistance owing to antimicrobial use in animal production. We have reported that...
10.
Virulence of Emerging Arthrotropic Avian Reoviruses Correlates With Their Ability to Activate and Traffic Interferon-γ Producing Cytotoxic CD8 T Cells Into Gastrocnemius Tendon
Ayalew L, Ahmed K, Popowich S, Lockerbie B, Gupta A, Tikoo S, et al.
Front Microbiol . 2022 Apr; 13:869164. PMID: 35369435
Newly emerging arthrotropic avian reoviruses (ARVs) are genetically divergent, antigenically heterogeneous, and economically costly. Nevertheless, the mechanism of emerging ARV-induced disease pathogenesis and potential differences in virulence between virus genotypes...