Kevin W Plaxco
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Explore the profile of Kevin W Plaxco including associated specialties, affiliations and a list of published articles.
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210
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5343
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Recent Articles
11.
Li S, Dai J, Zhu M, Arroyo-Curras N, Li H, Wang Y, et al.
ACS Nano
. 2023 Sep;
17(18):18525-18538.
PMID: 37703911
The ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in the living body, in real time and for long durations, would improve our understanding...
12.
Chung J, Plaxco K, Sepunaru L
J Vis Exp
. 2023 Aug;
(198).
PMID: 37590554
Nanoimpact electrochemistry enables the time-resolved in situ characterization (e.g., size, catalytic activity) of single nanomaterial units, providing a means of elucidating heterogeneities that would be masked in ensemble studies. To...
13.
Roehrich B, Leung K, Gerson J, Kippin T, Plaxco K, Sepunaru L
ACS Sens
. 2023 Aug;
8(8):3051-3059.
PMID: 37584531
Electrochemical aptamer-based (EAB) sensors are capable of measuring the concentrations of specific molecules in vivo, in real time, and with a few-second time resolution. For their signal transduction mechanism, these...
14.
Friedel M, Werbovetz B, Drexelius A, Watkins Z, Bali A, Plaxco K, et al.
Lab Chip
. 2023 Jul;
23(14):3289-3299.
PMID: 37395135
The ability to continually collect diagnostic information from the body during daily activity has revolutionized the monitoring of health and disease. Much of this monitoring, however, has been of physical...
15.
Son K, Uzawa T, Ito Y, Kippin T, Plaxco K, Fujie T
Biochem Biophys Res Commun
. 2023 May;
668:1-7.
PMID: 37230045
The ability to monitor levels of endogenous markers and clearance profiles of drugs and their metabolites can improve the quality of biomedical research and precision with which therapies are individualized....
16.
Gerson J, Erdal M, McDonough M, Ploense K, Dauphin-Ducharme P, Honeywell K, et al.
Sci Adv
. 2023 May;
9(20):eadg3254.
PMID: 37196087
Knowledge of drug concentrations in the brains of behaving subjects remains constrained on a number of dimensions, including poor temporal resolution and lack of real-time data. Here, however, we demonstrate...
17.
McDonough M, Stocker S, Kippin T, Meiring W, Plaxco K
Br J Clin Pharmacol
. 2023 May;
89(9):2798-2812.
PMID: 37186478
Aim: Pharmacokinetics have historically been assessed using drug concentration data obtained via blood draws and bench-top analysis. The cumbersome nature of these typically constrains studies to at most a dozen...
18.
Leung K, Gerson J, Emmons N, Roehrich B, Verrinder E, Fetter L, et al.
Analyst
. 2023 Mar;
148(7):1562-1569.
PMID: 36891771
Electrochemical, aptamer-based (EAB) sensors are the first molecular monitoring technology that is (1) based on receptor binding and not the reactivity of the target, rendering it fairly general, and (2)...
19.
Flatebo C, Conkright W, Beckner M, Batchelor R, Kippin T, Heikenfeld J, et al.
J Sci Med Sport
. 2023 Feb;
26 Suppl 1:S46-S53.
PMID: 36841706
Objectives: Technologies supporting the continuous, real-time measurement of blood oxygen saturation and plasma glucose levels have improved our ability to monitor performance status. Our ability to monitor other molecular markers...
20.
Ortega G, Chamorro-Garcia A, Ricci F, Plaxco K
Annu Rev Biophys
. 2023 Feb;
52:319-337.
PMID: 36737603
Cooperativity (homotropic allostery) is the primary mechanism by which evolution steepens the binding curves of biomolecular receptors to produce more responsive input-output behavior in biomolecular systems. Motivated by the ubiquity...