Gabriel Ortega
Overview
Explore the profile of Gabriel Ortega including associated specialties, affiliations and a list of published articles.
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31
Citations
452
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Recent Articles
1.
Ortega G, Chamorro-Garcia A, Ricci F, Plaxco K
Annu Rev Biophys
. 2023 Feb;
52:319-337.
PMID: 36737603
Cooperativity (homotropic allostery) is the primary mechanism by which evolution steepens the binding curves of biomolecular receptors to produce more responsive input-output behavior in biomolecular systems. Motivated by the ubiquity...
2.
Chamorro-Garcia A, Parolo C, Ortega G, Idili A, Green J, Ricci F, et al.
Chem Sci
. 2022 Nov;
13(41):12219-12228.
PMID: 36349092
Biosensors and bioassays, both of which employ proteins and nucleic acids to detect specific molecular targets, have seen significant applications in both biomedical research and clinical practice. This success is...
3.
Rosati G, Urban M, Zhao L, Yang Q, de Carvalho Castro E Silva C, Bonaldo S, et al.
Biosens Bioelectron
. 2021 Nov;
196:113737.
PMID: 34740116
Simplicity is one of the key feature for the spread of any successful technological product. Here, a method for rapid and low-cost fabrication of electrochemical biosensors is presented. This "plug,...
4.
Ortega G, Aguilar M, Gautam B, Plaxco K
Protein Sci
. 2021 Oct;
30(12):2408-2417.
PMID: 34719069
The interactions of proteins with surfaces are important in both biological processes and biotechnologies. In contrast to decades of study regarding the biophysics of proteins in bulk solution, however, our...
5.
Chamorro-Garcia A, Ortega G, Mariottini D, Green J, Ricci F, Plaxco K
Chem Commun (Camb)
. 2021 Oct;
57(88):11693-11696.
PMID: 34673866
Electrochemical aptamer-based (EAB) sensors, composed of an electrode-bound DNA aptamer with a redox reporter on the distal end, offer the promise of high-frequency, real-time molecular measurements in complex sample matrices...
6.
Parolo C, Greenwood A, Ogden N, Kang D, Hawes C, Ortega G, et al.
Microsyst Nanoeng
. 2021 Sep;
6:13.
PMID: 34567628
The multiplexed, point-of-care measurement of specific antibodies could improve the speed with which diseases are diagnosed and their treatment initiated. To this end, we are developing E-DNA scaffold sensors, which...
7.
Leung K, Downs A, Ortega G, Kurnik M, Plaxco K
ACS Sens
. 2021 Sep;
6(9):3340-3347.
PMID: 34491055
The ability to monitor drugs, metabolites, hormones, and other biomarkers in situ in the body would greatly advance both clinical practice and biomedical research. To this end, we are developing...
8.
Mateos B, Bernardo-Seisdedos G, Dietrich V, Zalba N, Ortega G, Peccati F, et al.
Biophys J
. 2021 Apr;
120(10):2067-2077.
PMID: 33794151
Protein oligomerization processes are widespread and of crucial importance to understand degenerative diseases and healthy regulatory pathways. One particular case is the homo-oligomerization of folded domains involving domain swapping, often...
9.
Ortega G, Kurnik M, Gautam B, Plaxco K
J Am Chem Soc
. 2020 Aug;
142(36):15349-15354.
PMID: 32786756
The physics of proteins interacting with surfaces can differ significantly from those seen when the same proteins are free in bulk solution. As an example, we describe here the extent...
10.
Ortega G, Mariottini D, Troina A, Dahlquist F, Ricci F, Plaxco K
Proc Natl Acad Sci U S A
. 2020 Jul;
117(32):19136-19140.
PMID: 32727893
Cooperativity enhances the responsiveness of biomolecular receptors to small changes in the concentration of their target ligand, albeit with a concomitant reduction in affinity. The binding midpoint of a two-site...