Kevin Strange
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Explore the profile of Kevin Strange including associated specialties, affiliations and a list of published articles.
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64
Citations
1786
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Recent Articles
1.
Karakas E, Strange K, Denton J
J Physiol
. 2025 Feb;
PMID: 39977537
Volume-regulated anion channels (VRACs) encoded by the LRRC8 gene family play essential roles in diverse and fundamentally important physiological processes in vertebrate cells. The recent determination of high-resolution cryo-electron microscopy...
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Takahashi H, Yamada T, Denton J, Strange K, Karakas E
Elife
. 2023 Mar;
12.
PMID: 36897307
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels...
4.
Yamada T, Figueroa E, Denton J, Strange K
Am J Physiol Cell Physiol
. 2020 Dec;
320(3):C293-C303.
PMID: 33356947
Swelling-activated volume-regulated anion channels (VRACs) are heteromeric channels comprising LRRC8A and at least one other LRRC8 paralog. Cryoelectron microscopy (cryo-EM) structures of nonnative LRRC8A and LRRC8D homohexamers have been described....
5.
Figueroa E, Kramer M, Strange K, Denton J
Am J Physiol Cell Physiol
. 2019 Aug;
317(4):C857-C866.
PMID: 31390227
Volume-regulated anion channels (VRACs) encoded by the leucine-rich repeat containing 8 () gene family play critical roles in myriad cellular processes and might represent druggable targets. The dearth of pharmacological...
6.
Strange K, Yamada T, Denton J
J Gen Physiol
. 2019 Jan;
151(2):100-117.
PMID: 30651298
The swelling-activated anion channel VRAC has fascinated and frustrated physiologists since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical properties and have shown that it plays...
7.
Yamada T, Strange K
J Gen Physiol
. 2018 Jun;
150(7):1003-1015.
PMID: 29853476
The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of Cl and organic solutes. Recent studies by several laboratories have demonstrated conclusively that VRAC...
8.
Strange K
ILAR J
. 2017 Jan;
57(2):133-143.
PMID: 28053067
Nonmammalian model organisms such as the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the zebrafish Danio rerio provide numerous experimental advantages for drug discovery including genetic and molecular...
9.
Yamada T, Strange K
Biophys J
. 2016 Nov;
111(9):1887-1896.
PMID: 27806270
CLC anion channels are homodimeric proteins. Each subunit is comprised of 18 α-helices designated "A-R" and an intracellular carboxy-terminus containing two cystathionine-β-synthase (CBS1 and CBS2) domains. Conformational coupling between membrane...
10.
Yamada T, Krzeminski M, Bozoky Z, Forman-Kay J, Strange K
Biophys J
. 2016 Nov;
111(9):1876-1886.
PMID: 27806269
Eukaryotic CLC anion channels and transporters are homodimeric proteins composed of multiple α-helical membrane domains and large cytoplasmic C-termini containing two cystathionine-β-synthase domains (CBS1 and CBS2) that dimerize to form...