Kevin Sharp
Overview
Explore the profile of Kevin Sharp including associated specialties, affiliations and a list of published articles.
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15
Citations
5801
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Recent Articles
1.
Thompson D, Wells D, Selzam S, Peneva I, Moore R, Sharp K, et al.
PLoS One
. 2024 Sep;
19(9):e0307270.
PMID: 39292644
We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals...
2.
Maltman N, Guilfoyle J, Nayar K, Martin G, Winston M, Lau J, et al.
Front Psychiatry
. 2021 Aug;
12:718485.
PMID: 34421690
The gene in its premutation (PM) state has been linked to a range of clinical and subclinical phenotypes among PM carriers, including some subclinical traits associated with autism spectrum disorder...
3.
Smith S, Douaud G, Chen W, Hanayik T, Alfaro-Almagro F, Sharp K, et al.
Nat Neurosci
. 2021 Apr;
24(5):737-745.
PMID: 33875891
UK Biobank is a major prospective epidemiological study, including multimodal brain imaging, genetics and ongoing health outcomes. Previously, we published genome-wide associations of 3,144 brain imaging-derived phenotypes, with a discovery...
4.
Winston M, Nayar K, Landau E, Maltman N, Sideris J, Zhou L, et al.
Front Genet
. 2021 Feb;
12:591211.
PMID: 33633778
Atypical visual attention patterns have been observed among carriers of the fragile X mental retardation gene () premutation (PM), with some similarities to visual attention patterns observed in autism spectrum...
5.
Budimirovic D, Schlageter A, Filipovic-Sadic S, Protic D, Bram E, Mahone E, et al.
Brain Sci
. 2020 Oct;
10(10).
PMID: 33008014
Fragile X syndrome (FXS) is caused by silencing of the gene, which encodes a protein with a critical role in synaptic plasticity. The molecular abnormality underlying silencing, CGG repeat expansion,...
6.
Bowling H, Kasper A, Patole C, Venkatasubramani J, Leventer S, Carmody E, et al.
J Proteome Res
. 2020 Aug;
19(9):3856-3866.
PMID: 32786687
Aberrant protein synthesis and protein expression are a hallmark of many conditions ranging from cancer to Alzheimer's. Blood-based biomarkers indicative of changes in proteomes have long been held to be...
7.
Winston M, Nayar K, Hogan A, Barstein J, La Valle C, Sharp K, et al.
Physiol Behav
. 2019 Nov;
214:112746.
PMID: 31765665
The FMR1 gene is associated with a wide range of clinical and cognitive phenotypes, ranging from intellectual disability and autism symptoms in fragile X syndrome (caused by the FMR1 full...
8.
Nayar K, McKinney W, Hogan A, Martin G, La Valle C, Sharp K, et al.
PLoS One
. 2019 Jul;
14(7):e0219924.
PMID: 31348790
The FMR1 premutation (PM) is relatively common in the general population. Evidence suggests that PM carriers may exhibit subtle differences in specific cognitive and language abilities. This study examined potential...
9.
Bowling H, Bhattacharya A, Zhang G, Alam D, Lebowitz J, Bohm-Levine N, et al.
Nat Commun
. 2019 Apr;
10(1):1710.
PMID: 30979884
Whether fragile X mental retardation protein (FMRP) target mRNAs and neuronal activity contributing to elevated basal neuronal protein synthesis in fragile X syndrome (FXS) is unclear. Our proteomic experiments reveal...
10.
Bycroft C, Freeman C, Petkova D, Band G, Elliott L, Sharp K, et al.
Nature
. 2018 Oct;
562(7726):203-209.
PMID: 30305743
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69...