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Kevin R Webster

Explore the profile of Kevin R Webster including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 488
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Recent Articles
1.
Gerson-Gurwitz A, Young N, Goel V, Eam B, Stumpf C, Chen J, et al.
Front Oncol . 2021 Dec; 11:766298. PMID: 34900714
Oncoprotein expression is controlled at the level of mRNA translation and is regulated by the eukaryotic translation initiation factor 4F (eIF4F) complex. eIF4A, a component of eIF4F, catalyzes the unwinding...
2.
Jana S, Deo R, Hough R, Liu Y, Horn J, Wright J, et al.
JCI Insight . 2021 May; 6(11). PMID: 34032633
Using genetically engineered mouse models, this work demonstrates that protein synthesis is essential for efficient urothelial cancer formation and growth but dispensable for bladder homeostasis. Through a candidate gene analysis...
3.
Erlanson D, Webster K
Curr Opin Chem Biol . 2021 Apr; 62:101-108. PMID: 33838397
The protein KRAS has for decades been considered a holy grail of cancer drug discovery. For most of that time, it has also been considered undruggable. Since 2018, five compounds...
4.
Thompson P, Eam B, Young N, Fish S, Chen J, Barrera M, et al.
Mol Cancer Ther . 2020 Oct; 20(1):26-36. PMID: 33037136
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and...
5.
Shukla T, de la Pena J, Perish J, Ploski J, Stumpf C, Webster K, et al.
Neurotherapeutics . 2020 Oct; 18(1):624-639. PMID: 33006091
Fragile X syndrome (FXS) is the most common inherited source of intellectual disability in humans. FXS is caused by mutations that trigger epigenetic silencing of the Fmr1 gene. Loss of...
6.
Ernst J, Thompson P, Nilewski C, Sprengeler P, Sperry S, Packard G, et al.
J Med Chem . 2020 May; 63(11):5879-5955. PMID: 32470302
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the...
7.
Xu Y, Poggio M, Jin H, Shi Z, Forester C, Wang Y, et al.
Nat Med . 2019 Jan; 25(2):301-311. PMID: 30643286
Cancer cells develop mechanisms to escape immunosurveillance, among which modulating the expression of immune suppressive messenger RNAs is most well-documented. However, how this is molecularly achieved remains largely unresolved. Here,...
8.
Megat S, Ray P, Moy J, Lou T, Barragan-Iglesias P, Li Y, et al.
J Neurosci . 2018 Nov; 39(3):393-411. PMID: 30459229
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including...
9.
Reich S, Sprengeler P, Chiang G, Appleman J, Chen J, Clarine J, et al.
J Med Chem . 2018 Mar; 61(8):3516-3540. PMID: 29526098
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways...
10.