Kevin M Myles
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Explore the profile of Kevin M Myles including associated specialties, affiliations and a list of published articles.
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45
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1121
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Recent Articles
1.
Gupta A, Chennuri P, Monfardini R, Myles K
bioRxiv
. 2025 Feb;
PMID: 39990464
RNA interference (RNAi) pathways are crucial for regulating viral infections in both animals and plants, acting as defense mechanisms that limit pathogen replication. This has led to the evolution of...
2.
Chennuri P, Zapletal J, Monfardini R, Ndeffo-Mbah M, Adelman Z, Myles K
PLoS Genet
. 2024 Nov;
20(11):e1011450.
PMID: 39509462
Here, we demonstrate that single strand annealing (SSA) can be co-opted for the precise autocatalytic excision of a drive element. We have termed this technology Repeat Mediated Excision of a...
3.
Chae K, Contreras B, Romanowski J, Dawson C, Myles K, Adelman Z
Commun Biol
. 2024 May;
7(1):660.
PMID: 38811748
While gene drive strategies have been proposed to aid in the control of mosquito-borne diseases, additional genome engineering technologies may be required to establish a defined end-of-product-life timeline. We previously...
4.
Chennuri P, Zapletal J, Monfardini R, Ndeffo-Mbah M, Adelman Z, Myles K
bioRxiv
. 2023 Dec;
PMID: 38045402
We demonstrate here that single strand annealing (SSA) repair can be co-opted for the precise autocatalytic excision of a drive element. Although SSA is not the predominant form of DNA...
5.
Bennett J, Wu S, Chennuri P, Myles K, Ndeffo-Mbah M
BMC Res Notes
. 2023 Oct;
16(1):258.
PMID: 37798614
Objective: The MGDrivE (MGDrivE 1 and MGDrivE 2) modeling framework provides a flexible and expansive environment for testing the efficacy of novel gene-drive constructs for the control of mosquito-borne diseases....
6.
Chae K, Overcash J, Dawson C, Valentin C, Tsujimoto H, Myles K, et al.
Curr Res Biotechnol
. 2023 Jul;
5.
PMID: 37475832
To maintain genome stability, eukaryotic cells orchestrate DNA repair pathways to process DNA double-strand breaks (DSBs) that result from diverse developmental or environmental stimuli. Bias in the selection of DSB...
7.
Samuel G, Pohlenz T, Dong Y, Coskun N, Adelman Z, Dimopoulos G, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2213701120.
PMID: 36893279
While it has long been known that the transmission of mosquito-borne viruses depends on the establishment of persistent and nonlethal infections in the invertebrate host, specific roles for the insects'...
8.
Chae K, Dawson C, Valentin C, Contreras B, Zapletal J, Myles K, et al.
PNAS Nexus
. 2023 Jan;
1(2):pgac037.
PMID: 36713320
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that...
9.
Chennuri P, Adelman Z, Myles K
Front Bioeng Biotechnol
. 2022 Jul;
10:897231.
PMID: 35782500
CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species. However, there...
10.
Khan S, Jakes E, Myles K, Adelman Z
Sci Rep
. 2021 Oct;
11(1):21553.
PMID: 34711911
No abstract available.