Kevin M Manz
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Explore the profile of Kevin M Manz including associated specialties, affiliations and a list of published articles.
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13
Citations
120
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Recent Articles
1.
Manz K, Zepeda J, Zurawski Z, Hamm H, Grueter B
Front Cell Neurosci
. 2023 May;
17:1165261.
PMID: 37206665
The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. These behaviors depend on the precise neuromodulatory actions of G-coupled G-protein-coupled receptors (GPCRs)...
2.
Liu J, Wu R, Seaman Jr R, Manz K, Johnson B, Vu J, et al.
Mol Psychiatry
. 2022 Jan;
27(4):2136-2145.
PMID: 35079125
Relapse remains a major challenge to the treatment of cocaine addiction. Recent studies suggested that the trace amine-associated receptor 1 (TAAR1) could be a promising target to treat cocaine addiction...
3.
Manz K, Brady L, Calipari E, Grueter B
Biol Psychiatry
. 2021 Dec;
93(11):1041-1052.
PMID: 34953589
Background: Central histamine (HA) signaling modulates diverse cortical and subcortical circuits throughout the brain, including the nucleus accumbens (NAc). The NAc, a key striatal subregion directing reward-related behavior, expresses diverse...
4.
Manz K, Coleman B, Jameson A, Ghose D, Patel S, Grueter B
Neuropsychopharmacology
. 2021 Sep;
47(3):652-663.
PMID: 34545194
Parvalbumin-expressing fast-spiking interneurons (PV-INs) within feedforward microcircuits in the nucleus accumbens (NAc) coordinate goal-directed motivational behavior. Feedforward inhibition of medium spiny projection neurons (MSNs) is initiated by glutamatergic input from...
5.
Coleman B, Manz K, Grueter B
Neuropsychopharmacology
. 2021 Aug;
46(13):2340-2349.
PMID: 34400782
The dynorphin/kappa opioid receptor (KOR) system within the nucleus accumbens (NAc) contributes to affective states. Parvalbumin fast-spiking interneurons (PV-FSIs), a key component of feedforward inhibition, participate in integration of excitatory...
6.
Manz K, Siemann J, McMahon D, Grueter B
STAR Protoc
. 2021 Apr;
2(2):100442.
PMID: 33899023
Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp recordings in brain slices can be performed in voltage-clamp and current-clamp...
7.
Manz K, Coleman B, Grueter C, Shields B, Tadross M, Grueter B
J Neurosci
. 2021 Mar;
41(17):3752-3763.
PMID: 33737458
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with...
8.
Turner B, Smith N, Manz K, Chang B, Delpire E, Grueter C, et al.
Psychopharmacology (Berl)
. 2021 Jan;
238(4):1121-1131.
PMID: 33454843
Rationale: Cannabinoid type 1 receptors (CB1Rs) are widely expressed within the brain's reward circuits and are implicated in regulating drug induced behavioral adaptations. Understanding how CB1R signaling in discrete circuits...
9.
Manz K, Becker J, Grueter C, Grueter B
Biol Psychiatry
. 2020 Oct;
89(6):588-599.
PMID: 33012522
Background: Histamine (HA), a wake-promoting monoamine implicated in stress-related arousal states, is synthesized in histidine decarboxylase-expressing hypothalamic neurons of the tuberomammillary nucleus. Histidine decarboxylase-containing varicosities diffusely innervate striatal and mesolimbic...
10.
Manz K, Ghose D, Turner B, Taylor A, Becker J, Grueter C, et al.
Cell Rep
. 2020 Jul;
32(4):107971.
PMID: 32726634
Synaptic plasticity is a key mechanism of learning and memory. Synaptic plasticity mechanisms within the nucleus accumbens (NAc) mediate differential behavioral adaptations. Feedforward inhibition in the NAc occurs when glutamatergic...