Kevin Liaw
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Explore the profile of Kevin Liaw including associated specialties, affiliations and a list of published articles.
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31
Citations
429
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Recent Articles
11.
Tallon C, Sharma A, Zhang Z, Thomas A, Ng J, Zhu X, et al.
Neurotherapeutics
. 2022 Jan;
19(1):274-288.
PMID: 34984651
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease where muscle weakness and neuromuscular junction (NMJ) denervation precede motor neuron cell death. Although acetylcholine is the canonical neurotransmitter at the...
12.
Hollinger K, Sharma A, Tallon C, Lovell L, Thomas A, Zhu X, et al.
Nanotheranostics
. 2022 Jan;
6(2):126-142.
PMID: 34976589
Cognitive impairment is a common aspect of multiple sclerosis (MS) for which there are no treatments. Reduced brain -acetylaspartylglutamate (NAAG) levels are linked to impaired cognition in various neurological diseases,...
13.
Harris M, Kuang H, Schneiderman Z, Shiao M, Crane A, Chrostek M, et al.
Sci Adv
. 2021 Dec;
7(49):eabl5872.
PMID: 34851666
Effective treatment of glioblastoma remains a daunting challenge. One of the major hurdles in the development of therapeutics is their inability to cross the blood-brain tumor barrier (BBTB). Local delivery...
14.
Sharma R, Liaw K, Sharma A, Jimenez A, Chang M, Salazar S, et al.
J Control Release
. 2021 Jul;
337:179-192.
PMID: 34274384
Glioblastoma is among the most aggressive forms of cancers, with a median survival of just 15-20 months for patients despite maximum clinical intervention. The majority of conventional anti-cancer therapies fail...
15.
Gary E, Warner B, Parzych E, Griffin B, Zhu X, Tailor N, et al.
iScience
. 2021 Jun;
24(7):102699.
PMID: 34124612
More than 100 million people have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Common laboratory mice are not susceptible to wild-type SARS-CoV-2 infection, challenging the development and testing...
16.
Liaw K, Reddy R, Sharma A, Li J, Chang M, Sharma R, et al.
Bioeng Transl Med
. 2021 May;
6(2):e10205.
PMID: 34027092
Glioblastoma is the most common and aggressive form of primary brain cancer, with median survival of 16-20 months and a 5-year survival rates of <5%. Recent advances in immunotherapies have...
17.
DeRidder L, Sharma A, Liaw K, Sharma R, John J, Kannan S, et al.
Nanoscale
. 2021 Jan;
13(2):939-952.
PMID: 33479718
Switching microglia from a disease exacerbating, 'pro-inflammatory' state into a neuroprotective, 'anti-inflammatory' phenotype is a promising strategy for addressing multiple neurodegenerative diseases. Pro-inflammatory microglia contribute to disease progression by releasing...
18.
Liaw K, Sharma R, Sharma A, Salazar S, La Rosa S, Kannan R
J Control Release
. 2020 Dec;
329:434-444.
PMID: 33290796
Novel delivery strategies are necessary to effectively address glioblastoma without systemic toxicities. Triptolide is a therapy derived from the thunder god vine that has shown potent anti-proliferative and immunosuppressive properties...
19.
Sharma A, Liaw K, Sharma R, Spriggs T, La Rosa S, Kannan S, et al.
Biomacromolecules
. 2020 Oct;
21(12):5148-5161.
PMID: 33112134
Glioblastoma exhibits high mortality rates due to challenges with drug delivery to the brain and into solid tumors. This two-pronged barrier necessitates high doses of systemic therapies, resulting in significant...
20.
Sharma A, Liaw K, Sharma R, Thomas A, Slusher B, Kannan S, et al.
Biomacromolecules
. 2020 Aug;
21(9):3909-3922.
PMID: 32786523
Mitochondria mediate critical cellular processes, including proliferation, apoptosis, and immune responses; as such, their dysfunction is pathogenic in many neurodegenerative disorders and cancers. In glioblastoma, targeted delivery of mitochondria-focused anticancer...