Kevin K Parker
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Explore the profile of Kevin K Parker including associated specialties, affiliations and a list of published articles.
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22
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2054
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Recent Articles
11.
Sheehy S, Grosberg A, Qin P, Behm D, Ferrier J, Eagleson M, et al.
Exp Biol Med (Maywood)
. 2017 Mar;
242(17):1643-1656.
PMID: 28343439
In vitro studies of cardiac physiology and drug response have traditionally been performed on individual isolated cardiomyocytes or isotropic monolayers of cells that may not mimic desired physiological traits of...
12.
Benam K, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante T, Choe Y, et al.
Cell Syst
. 2016 Nov;
3(5):456-466.e4.
PMID: 27894999
Smoking represents a major risk factor for chronic obstructive pulmonary disease (COPD), but it is difficult to characterize smoke-induced injury responses under physiological breathing conditions in humans due to patient-to-patient...
13.
Lind J, Busbee T, Valentine A, Pasqualini F, Yuan H, Yadid M, et al.
Nat Mater
. 2016 Nov;
16(3):303-308.
PMID: 27775708
Biomedical research has relied on animal studies and conventional cell cultures for decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that recapitulate the structure and function of native tissues...
14.
Chal J, Al Tanoury Z, Hestin M, Gobert B, Aivio S, Hick A, et al.
Nat Protoc
. 2016 Sep;
11(10):1833-50.
PMID: 27583644
Progress toward finding a cure for muscle diseases has been slow because of the absence of relevant cellular models and the lack of a reliable source of muscle progenitors for...
15.
Maia P, Hemphill M, Zehnder B, Zhang C, Parker K, Kutz J
J Neurosci Methods
. 2015 Jul;
253:233-43.
PMID: 26188255
Background: Focal Axonal Swellings arise in several leading neurodegenerative diseases of the central nervous system and are hallmark features of concussions and traumatic brain injuries. Recent theories mapped how the...
16.
Benam K, Dauth S, Hassell B, Herland A, Jain A, Jang K, et al.
Annu Rev Pathol
. 2015 Jan;
10:195-262.
PMID: 25621660
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of human disease or to develop new and improved therapies or diagnostics. Although great advances have...
17.
Kuo P, Lee H, Bray M, Geisse N, Huang Y, Adams W, et al.
Am J Pathol
. 2012 Nov;
181(6):2030-7.
PMID: 23159216
The heart actively remodels architecture in response to various physiological and pathological conditions. Gross structural change of the heart chambers is directly reflected at the cellular level by altering the...
18.
Dvir T, Timko B, Brigham M, Naik S, Karajanagi S, Levy O, et al.
Nat Nanotechnol
. 2011 Sep;
6(11):720-5.
PMID: 21946708
Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds. These biomaterials, which are usually made...
19.
Bray M, Adams W, Geisse N, Feinberg A, Sheehy S, Parker K
Biomaterials
. 2010 Apr;
31(19):5143-50.
PMID: 20382423
Cardiac tissue engineering requires finely-tuned manipulation of the extracellular matrix (ECM) microenvironment to optimize internal myocardial organization. The myocyte nucleus is mechanically connected to the cell membrane via cytoskeletal elements,...
20.
Alford P, Feinberg A, Sheehy S, Parker K
Biomaterials
. 2010 Feb;
31(13):3613-21.
PMID: 20149449
In vitro cardiovascular disease models need to recapitulate tissue-scale function in order to provide in vivo relevance. We have developed a new method for measuring the contractility of engineered cardiovascular...