Kevin K Parker
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Explore the profile of Kevin K Parker including associated specialties, affiliations and a list of published articles.
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22
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2054
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Recent Articles
1.
Lu F, Liou C, Ma Q, Wu Z, Xue B, Xia Y, et al.
Nat Biomed Eng
. 2024 Sep;
PMID: 39237710
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) lack nanoscale structures essential for efficient excitation-contraction coupling. Such nanostructures, known as dyads, are frequently disrupted in heart failure. Here we...
2.
Prondzynski M, Bortolin R, Berkson P, Trembley M, Shani K, Sweat M, et al.
bioRxiv
. 2024 Mar;
PMID: 38464269
In the last decade human iPSC-derived cardiomyocytes (hiPSC-CMs) proved to be valuable for cardiac disease modeling and cardiac regeneration, yet challenges with scale, quality, inter-batch consistency, and cryopreservation remain, reducing...
3.
Lee K, Nguyen H, Setiawati A, Nam S, Kim M, Ko I, et al.
Adv Healthc Mater
. 2021 Nov;
11(4):e2101599.
PMID: 34800312
The unfolded states of fibronectin (FN) subsequently induce the formation of an extracellular matrix (ECM) fibrillar network, which is necessary to generate new substitutive tissues. Here, the authors demonstrate that...
4.
Ricotti L, Trimmer B, Feinberg A, Raman R, Parker K, Bashir R, et al.
Sci Robot
. 2020 Nov;
2(12).
PMID: 33157905
Actuation is essential for artificial machines to interact with their surrounding environment and to accomplish the functions for which they are designed. Over the past few decades, there has been...
5.
Fioretta E, Motta S, Lintas V, Loerakker S, Parker K, Baaijens F, et al.
Nat Rev Cardiol
. 2020 Sep;
18(2):92-116.
PMID: 32908285
Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve repair or replacement has been the standard of care for patients with valvular heart disease for...
6.
OConnor B, Pope B, Peters M, Ris-Stalpers C, Parker K
Exp Biol Med (Maywood)
. 2020 Jul;
245(13):1163-1174.
PMID: 32640894
Extracellular matrix in the womb regulates the initiation, progression, and completion of a healthy pregnancy. The composition and physical properties of extracellular matrix in the uterus and at the maternal-fetal...
7.
Herland A, Maoz B, Das D, Somayaji M, Prantil-Baun R, Novak R, et al.
Nat Biomed Eng
. 2020 Jan;
4(4):421-436.
PMID: 31988459
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD modelling does...
8.
Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, et al.
Nat Biomed Eng
. 2020 Jan;
4(4):407-420.
PMID: 31988458
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom software and...
9.
Lind J, Yadid M, Perkins I, OConnor B, Eweje F, Chantre C, et al.
Lab Chip
. 2017 Oct;
17(21):3692-3703.
PMID: 28976521
Microphysiological systems and organs-on-chips promise to accelerate biomedical and pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from addressing the physiological accuracy of the model tissues,...
10.
Generali M, Kehl D, Capulli A, Parker K, Hoerstrup S, Weber B
Colloids Surf B Biointerfaces
. 2017 Jul;
158:203-212.
PMID: 28697435
Biodegradable scaffold matrixes form the basis of any in vitro tissue engineering approach by acting as a temporary matrix for cell proliferation and extracellular matrix deposition until the scaffold is...