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Kevin J Schwarz

Explore the profile of Kevin J Schwarz including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 186
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Recent Articles
1.
Kim D, Watkins A, Bidstrup E, Lee J, Topkar V, Kofman C, et al.
Nat Chem Biol . 2022 Jul; 18(9):990-998. PMID: 35836020
RNA-based macromolecular machines, such as the ribosome, have functional parts reliant on structural interactions spanning sequence-distant regions. These features limit evolutionary exploration of mutant libraries and confound three-dimensional structure-guided design....
2.
Stawiasz K, Paul J, Schwarz K, Sottos N, Moore J
ACS Macro Lett . 2022 May; 9(11):1563-1568. PMID: 35617057
In this work, a simple method is reported for control over initiation in frontal ring-opening metathesis polymerization (FROMP). This noncontact approach uses 375 nm light to excite Grubbs' second-generation catalyst...
3.
Lee J, Schwarz K, Yu H, Kruger A, Anslyn E, Ellington A, et al.
Chem Commun (Camb) . 2021 Feb; 57(21):2661-2664. PMID: 33592078
We report the design, chemical synthesis, and flexizyme-catalyzed transfer RNA (tRNA) acylation of a variety of fluorescent amino acids (FAAs). The fluorescent groups include pyrene, coumarin, nitrobenzoxadiazole, and fluorescein variants....
4.
Lee J, Schwarz K, Kim D, Moore J, Jewett M
Nat Commun . 2020 Aug; 11(1):4304. PMID: 32855412
Ribosome-mediated polymerization of backbone-extended monomers into polypeptides is challenging due to their poor compatibility with the translation apparatus, which evolved to use α-L-amino acids. Moreover, mechanisms to acylate (or charge)...
5.
Lee J, Schwieter K, Watkins A, Kim D, Yu H, Schwarz K, et al.
Nat Commun . 2019 Nov; 10(1):5097. PMID: 31704912
The site-specific incorporation of noncanonical monomers into polypeptides through genetic code reprogramming permits synthesis of bio-based products that extend beyond natural limits. To better enable such efforts, flexizymes (transfer RNA...
6.
Schwarz K, Yang C, Fyfe J, Snaddon T
Angew Chem Int Ed Engl . 2018 Jul; 57(37):12102-12105. PMID: 30011353
The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of...
7.
Schwarz K, Pearson C, Cintron-Rosado G, Liu P, Snaddon T
Angew Chem Int Ed Engl . 2018 Apr; 57(26):7800-7803. PMID: 29701289
Cooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters with 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and...
8.
Schwarz K, Amos J, Klein J, Do D, Snaddon T
J Am Chem Soc . 2016 Mar; 138(16):5214-7. PMID: 27028057
The direct, catalytic, asymmetric α-functionalization of acyclic esters constitutes a significant challenge in the area of asymmetric catalysis, particularly where the configurational integrity of the products is problematic. Through the...