Kevin J Cheung
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Explore the profile of Kevin J Cheung including associated specialties, affiliations and a list of published articles.
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24
Citations
2154
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Recent Articles
11.
Cheung K, Ewald A
Science
. 2016 Apr;
352(6282):167-9.
PMID: 27124449
Despite decades of study, there are still many unanswered questions about metastasis, the process by which a localized cancer becomes a systemic disease. One of these questions is the nature...
12.
Cheung K, Padmanaban V, Silvestri V, Schipper K, Cohen J, Fairchild A, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(7):E854-63.
PMID: 26831077
Recent genomic studies challenge the conventional model that each metastasis must arise from a single tumor cell and instead reveal that metastases can be composed of multiple genetically distinct clones....
13.
Nguyen-Ngoc K, Shamir E, Huebner R, Beck J, Cheung K, Ewald A
Methods Mol Biol
. 2014 Sep;
1189:135-62.
PMID: 25245692
Epithelia are fundamental tissues that line cavities, glands, and outer body surfaces. We use three-dimensional (3D) embedded culture of primary murine mammary epithelial ducts, called "organoids," to recapitulate in days...
14.
Cheung K, Ewald A
Curr Opin Cell Biol
. 2014 Aug;
30:99-111.
PMID: 25137487
Metastasis begins when tumors invade into surrounding tissues. In breast cancer, the study of cell interactions has provided fundamental insights into this complex process. Powerful intravital and 3D organoid culture...
15.
16.
Cheung K, Gabrielson E, Werb Z, Ewald A
Cell
. 2013 Dec;
155(7):1639-51.
PMID: 24332913
Carcinomas typically invade as a cohesive multicellular unit, a process termed collective invasion. It remains unclear how different subpopulations of cancer cells contribute to this process. We developed three-dimensional (3D)...
17.
Nguyen-Ngoc K, Cheung K, Brenot A, Shamir E, Gray R, Hines W, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(39):E2595-604.
PMID: 22923691
Breast cancer progression involves genetic changes and changes in the extracellular matrix (ECM). To test the importance of the ECM in tumor cell dissemination, we cultured epithelium from primary human...
18.
Ewald A, Huebner R, Palsdottir H, Lee J, Perez M, Jorgens D, et al.
J Cell Sci
. 2012 Feb;
125(Pt 11):2638-54.
PMID: 22344263
Normal mammary morphogenesis involves transitions between simple and multilayered epithelial organizations. We used electron microscopy and molecular markers to determine whether intercellular junctions and apico-basal polarity were maintained in the...
19.
Gray R, Cheung K, Ewald A
Curr Opin Cell Biol
. 2010 Sep;
22(5):640-50.
PMID: 20832275
The cellular mechanisms driving mammalian epithelial morphogenesis are of significant fundamental and practical interest. Historically, these processes have been difficult to study directly, owing to the opacity and relative inaccessibility...
20.
Cheung K, Ebert B
Pediatr Blood Cancer
. 2009 Apr;
53(2):131-2.
PMID: 19343773
No abstract available.