Kevin Hakala
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Explore the profile of Kevin Hakala including associated specialties, affiliations and a list of published articles.
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20
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511
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Recent Articles
1.
Lager S, Ramirez V, Acosta O, Meireles C, Miller E, Gaccioli F, et al.
J Clin Endocrinol Metab
. 2017 Oct;
102(12):4557-4567.
PMID: 29053802
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid...
2.
Padmanabhan Iyer R, Chiao Y, Flynn E, Hakala K, Cates C, Weintraub S, et al.
Proteomics Clin Appl
. 2015 Sep;
10(1):92-107.
PMID: 26415707
Purpose: Matrix metalloproteinases (MMPs) collectively degrade all extracellular matrix (ECM) proteins. Of the MMPs, MMP-9 has the strongest link to the development of cardiac dysfunction. Aging associates with increased MMP-9...
3.
Elzi D, Song M, Hakala K, Weintraub S, Shiio Y
J Proteome Res
. 2014 Jul;
13(8):3783-91.
PMID: 24999758
Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly Fli-1....
4.
Yabluchanskiy A, Li Y, de Castro Bras L, Hakala K, Weintraub S, Lindsey M
Methods Mol Biol
. 2013 Aug;
1066:185-99.
PMID: 23955744
Left ventricular remodeling post-myocardial infarction (MI) involves a multitude of mechanisms that regulate the repair response. Matrix metalloproteinases (MMPs) are a major family of proteolytic enzymes that coordinate extracellular matrix...
5.
de Castro Bras L, Ramirez T, DeLeon-Pennell K, Chiao Y, Ma Y, Dai Q, et al.
J Proteomics
. 2013 May;
86:43-52.
PMID: 23681174
Biological Significance: The study of extracellular matrix (ECM) proteins in pathological and non-pathological conditions is often hampered by the low solubility of ECM components in common solubilizing reagents. Additionally, ECM...
6.
Elzi D, Song M, Hakala K, Weintraub S, Shiio Y
Mol Cell Biol
. 2012 Aug;
32(21):4388-99.
PMID: 22927647
Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1...
7.
de Castro Bras L, Deleon K, Ma Y, Dai Q, Hakala K, Weintraub S, et al.
Int J Proteomics
. 2012 Jul;
2012:397103.
PMID: 22778955
Following myocardial infarction (MI), matrix metalloproteinase-9 (MMP-9) levels increase, and MMP-9 deletion improves post-MI remodeling of the left ventricle (LV). We provide here a technical report on plasma-analysis from wild...
8.
Elzi D, Lai Y, Song M, Hakala K, Weintraub S, Shiio Y
Proc Natl Acad Sci U S A
. 2012 Jul;
109(30):12052-7.
PMID: 22778398
Cellular senescence is widely believed to play a key role in tumor suppression, but the molecular pathways that regulate senescence are only incompletely understood. By using a secretome proteomics approach,...
9.
Lai Y, Song M, Hakala K, Weintraub S, Shiio Y
Arch Biochem Biophys
. 2012 Jan;
518(2):103-10.
PMID: 22234250
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor is associated with renal carcinoma, hemangioblastoma and pheochromocytoma. The VHL protein is a component of a ubiquitin ligase complex that ubiquitinates and...
10.
Song M, Hakala K, Weintraub S, Shiio Y
J Proteome Res
. 2011 Sep;
10(11):5191-8.
PMID: 21950761
Mutation of the BRCA1 tumor suppressor gene predisposes women to hereditary breast and ovarian cancers. BRCA1 forms a heterodimer with BARD1. The BRCA1/BARD1 heterodimer has ubiquitin ligase activity, considered to...