Kevin D Mangum
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Explore the profile of Kevin D Mangum including associated specialties, affiliations and a list of published articles.
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13
Citations
118
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Recent Articles
1.
Callow B, He X, Juriga N, Mangum K, Joshi A, Xing X, et al.
JCI Insight
. 2025 Jan;
10(2).
PMID: 39846252
Abdominal aortic aneurysms (AAA) are a life-threatening cardiovascular disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by...
2.
Mangum K, DenDekker A, Li Q, Tsoi L, Joshi A, Melvin W, et al.
JCI Insight
. 2024 Oct;
9(20).
PMID: 39435663
Macrophage transition from an inflammatory to reparative phenotype after tissue injury is controlled by epigenetic enzymes that regulate inflammatory gene expression. We have previously identified that the histone methyltransferase SETDB2...
3.
Melvin W, Bauer T, Mangum K, Audu C, Shadiow J, Barrett E, et al.
JCI Insight
. 2024 Sep;
9(19).
PMID: 39250432
Immune cell-mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of CD4+ T cells in normal or diabetic...
4.
Mangum K, Li Q, Bauer T, Wolf S, Shadiow J, Moon J, et al.
medRxiv
. 2024 Jul;
PMID: 39040193
Long-standing hypertension (HTN) affects multiple organ systems and leads to pathologic arterial remodeling, which is driven largely by smooth muscle cell (SMC) plasticity. Although genome wide association studies (GWAS) have...
5.
Audu C, Wolf S, Joshi A, Moon J, Melvin W, Sharma S, et al.
JCI Insight
. 2024 Jun;
9(12).
PMID: 38912581
Plasmacytoid dendritic cells (pDCs) are first responders to tissue injury, where they prime naive T cells. The role of pDCs in physiologic wound repair has been examined, but little is...
6.
Zou M, Mangum K, Magin J, Cao H, Yarboro M, Shelton E, et al.
JCI Insight
. 2023 Feb;
8(5).
PMID: 36749647
Based upon our demonstration that the smooth muscle cell-selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6's role in SMCs in vivo using cell type-specific knockout...
7.
Mangum K, Gallagher K
Science
. 2023 Jan;
379(6627):28-29.
PMID: 36603093
Epigenetic programming of myeloid cells in obesity contributes to macular degeneration.
8.
Audu C, Melvin W, Joshi A, Wolf S, Moon J, Davis F, et al.
Cell Mol Immunol
. 2022 Sep;
19(11):1251-1262.
PMID: 36127466
Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage plasticity is impaired, and macrophages remain in a persistent proinflammatory state; however, the...
9.
Mangum K, Farber M
Clin Genet
. 2020 Jan;
97(6):815-826.
PMID: 31957007
Abdominal aortic aneurysms (AAAs) are focal dilations of the aorta that develop from degenerative changes in the media and adventitia of the vessel. Ruptured AAAs have a mortality of up...
10.
Mangum K, Freeman E, Magin J, Taylor J, Mack C
Am J Physiol Heart Circ Physiol
. 2019 Dec;
318(2):H413-H424.
PMID: 31886719
We previously showed that ARHGAP42 is a smooth muscle cell (SMC)-selective, RhoA-specific GTPase activating protein that regulates blood pressure and that a minor allele single nucleotide variation within a DNAse...