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Kevin D Browne

Explore the profile of Kevin D Browne including associated specialties, affiliations and a list of published articles. Areas
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Articles 74
Citations 1263
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Recent Articles
1.
Wofford K, Browne K, Loane D, Meaney D, Cullen D
J Neuroinflammation . 2024 Dec; 21(1):324. PMID: 39696519
Traumatic brain injury (TBI) is a global health problem affecting millions of individuals annually, potentially resulting in persistent neuropathology, chronic neurological deficits, and death. However, TBI not only affects neural...
2.
Gordian-Velez W, Browne K, Galarraga J, Chouhan D, Duda J, Espana R, et al.
Adv Healthc Mater . 2024 Nov; 14(2):e2402997. PMID: 39494983
Parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long-projecting axons comprising the nigrostriatal pathway. To address this,...
3.
Bele P, Thaploo A, Coons M, Culkin M, Santos P, Martinez-Quinones P, et al.
J Trauma Acute Care Surg . 2024 May; 97(5):776-784. PMID: 38767935
Background: Traumatic brain injury (TBI) induces cognitive deficits driven by neuroinflammation and cerebral edema. The commonly used atypical antipsychotic, quetiapine (QTP), has been recently shown to improve post-TBI outcomes. We...
4.
Song H, Tomasevich A, Paolini A, Browne K, Wofford K, Kelley B, et al.
Acta Neuropathol . 2024 May; 147(1):79. PMID: 38705966
Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With increasing recognition that damage to white matter axons...
5.
Acero V, Cribas E, Browne K, Rivellini O, Burrell J, ODonnell J, et al.
Front Pharmacol . 2023 Oct; 14:1240295. PMID: 37869749
There has recently been a resurgence of interest in psychedelic compounds based on studies demonstrating their potential therapeutic applications in treating post-traumatic stress disorder, substance abuse disorders, and treatment-resistant depression....
6.
Culkin M, Coons M, Bele P, Thaploo A, Georges A, Anderson E, et al.
J Trauma Acute Care Surg . 2023 Oct; 96(1):26-34. PMID: 37853567
Background: Early but not late tranexamic acid (TXA) after TBI preserves blood-brain-barrier integrity, but it is unclear if and how dose timing affects cognitive recovery beyond hours postinjury. We hypothesized...
7.
Harris J, Mietus C, Browne K, Wofford K, Keating C, Brown D, et al.
Front Cell Neurosci . 2023 Jul; 17:1055455. PMID: 37519631
Closed-head traumatic brain injury (TBI) is induced by rapid motion of the head, resulting in diffuse strain fields throughout the brain. The injury mechanism(s), loading thresholds, and neuroanatomical distribution of...
8.
Grovola M, Jinich A, Paleologos N, Arroyo E, Browne K, Swanson R, et al.
Biomedicines . 2023 Jul; 11(7). PMID: 37509599
Traumatic brain injury (TBI) is a major contributor to morbidity and mortality in the United States as several million people visit the emergency department every year due to TBI exposures....
9.
ODonnell J, Browne K, Kvint S, Makaron L, Grovola M, Karandikar S, et al.
Biomedicines . 2023 May; 11(5). PMID: 37239007
Neurocritical care significantly impacts outcomes after moderate-to-severe acquired brain injury, but it is rarely applied in preclinical studies. We created a comprehensive neurointensive care unit (neuroICU) for use in swine...
10.
Struzyna L, Browne K, Burrell J, Velez W, Wofford K, Kaplan H, et al.
Int J Mol Sci . 2022 Nov; 23(22). PMID: 36430464
Parkinson's disease (PD) affects 1-2% of people over 65, causing significant morbidity across a progressive disease course. The classic PD motor deficits are caused by the degeneration of dopaminergic neurons...