Kevin D Browne
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Explore the profile of Kevin D Browne including associated specialties, affiliations and a list of published articles.
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74
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1263
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Recent Articles
11.
Smith D, Burrell J, Browne K, Katiyar K, Ezra M, Dutton J, et al.
Sci Adv
. 2022 Nov;
8(44):eabm3291.
PMID: 36332027
Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow axon growth rates and eventual regenerative pathway degradation in the absence of axons. We are developing tissue-engineered nerve...
12.
Burrell J, Das S, Laimo F, Katiyar K, Browne K, Shultz R, et al.
Bioact Mater
. 2022 Apr;
18:339-353.
PMID: 35415305
Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle....
13.
Petrov D, Burrell J, Browne K, Laimo F, Roberts S, Ali Z, et al.
Front Surg
. 2022 Mar;
9:811544.
PMID: 35341161
Facial nerve trauma often leads to disfiguring facial muscle paralysis. Despite several promising advancements, facial nerve repair procedures often do not lead to complete functional recovery. Development of novel repair...
14.
Wofford K, Grovola M, Adewole D, Browne K, Putt M, ODonnell J, et al.
Brain Commun
. 2021 Dec;
3(4):fcab268.
PMID: 34934944
Mild traumatic brain injury affects millions of individuals annually primarily through falls, traffic collisions, or blunt trauma and can generate symptoms that persist for years. Closed-head rotational loading is the...
15.
Shultz R, Katiyar K, Laimo F, Burrell J, Browne K, Ali Z, et al.
J Tissue Eng
. 2021 Aug;
12:20417314211032488.
PMID: 34394908
Tissue engineered nerve grafts (TENGs) built from living neurons and aligned axon tracts offer a revolutionary new approach as "living scaffolds" to bridge major peripheral nerve defects. Clinical application, however,...
16.
Grovola M, Paleologos N, Brown D, Tran N, Wofford K, Harris J, et al.
Brain Pathol
. 2021 May;
31(5):e12953.
PMID: 33960556
Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that are caused by...
17.
Keating C, Browne K, Cullen D
Exp Neurol
. 2021 Feb;
340:113649.
PMID: 33600812
Traumatic brain injury (TBI) can produce physical disruptions in the plasma membranes of neurons, referred to as mechanoporation, which lead to increased cell permeability. We suspect that such trauma-induced membrane...
18.
Katiyar K, Burrell J, Laimo F, Browne K, Bianchi J, Walters A, et al.
Tissue Eng Part A
. 2021 Jan;
27(19-20):1305-1320.
PMID: 33514288
Existing strategies for repair of major peripheral nerve injury (PNI) are inefficient at promoting axon regeneration and functional recovery and are generally ineffective for nerve lesions >5 cm. To address...
19.
Sullivan P, AlBayar A, Burrell J, Browne K, Arena J, Johnson V, et al.
Tissue Eng Part A
. 2021 Jan;
27(19-20):1264-1274.
PMID: 33430694
Regeneration after spinal cord injury (SCI) is limited by the presence of a glial scar and inhibitory cell signaling pathways that favor scar formation over regrowth of endogenous neurons. Tissue...
20.
Maggiore J, Burrell J, Browne K, Katiyar K, Laimo F, Ali Z, et al.
J Tissue Eng Regen Med
. 2020 Oct;
14(12):1892-1907.
PMID: 33049797
Peripheral nerve injury (PNI) impacts millions annually, often leaving debilitated patients with minimal repair options to improve functional recovery. Our group has previously developed tissue engineered nerve grafts (TENGs) featuring...