Kevin C OConnor
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Explore the profile of Kevin C OConnor including associated specialties, affiliations and a list of published articles.
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117
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4533
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Recent Articles
11.
Yandamuri S, Filipek B, Lele N, Cohen I, Bennett J, Nowak R, et al.
J Immunol
. 2024 Jan;
212(5):785-800.
PMID: 38251887
Neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein Ab disease, and autoimmune myasthenia gravis (MG) are autoantibody-mediated neurologic conditions where autoantibodies can induce Ab-dependent cellular cytotoxicity (ADCC), a NK cell-mediated...
12.
Bodansky A, Yu D, Rallistan A, Kalaycioglu M, Boonyaratanakornkit J, Green D, et al.
medRxiv
. 2024 Jan;
PMID: 38196603
The prevalence and burden of autoimmune and autoantibody mediated disease is increasing worldwide, yet most disease etiologies remain unclear. Despite numerous new targeted immunomodulatory therapies, comprehensive approaches to apply and...
13.
Bayer A, OConnor K
Sci Immunol
. 2023 Oct;
8(88):eadl0618.
PMID: 37801515
Curated expression of proteolipid protein 1 (PLP1) is essential for multiple sclerosis-derived autoantibody recognition.
14.
Schlatter M, Yandamuri S, OConnor K, Nowak R, Pham M, Obaid A, et al.
Ann Clin Transl Neurol
. 2023 Sep;
10(11):2105-2113.
PMID: 37726935
Objective: Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular junction disorder involving the acetylcholine receptors on the motor endplate. The safety and response to high-dose chemotherapy (HDIT) and autologous hematopoietic cell...
15.
Khani-Habibabadi F, OConnor K
Sci Immunol
. 2023 Aug;
8(86):eadj9555.
PMID: 37540737
Tissue-resident memory T cells accumulate in mucosal sites during infancy and then mature through childhood.
16.
Pham M, Masi G, Patzina R, Obaid A, Oxendine S, Oh S, et al.
Acta Neuropathol
. 2023 Jun;
146(2):319-336.
PMID: 37344701
Serum autoantibodies targeting the nicotinic acetylcholine receptor (AChR) in patients with autoimmune myasthenia gravis (MG) can mediate pathology via three distinct molecular mechanisms: complement activation, receptor blockade, and antigenic modulation....
17.
Jiang R, Roy B, Wu Q, Mohanty S, Nowak R, Shaw A, et al.
Immunohorizons
. 2023 May;
7(5):310-322.
PMID: 37171806
Inclusion body myositis (IBM) is an autoimmune and degenerative disorder of skeletal muscle. The B cell infiltrates in IBM muscle tissue are predominantly fully differentiated Ab-secreting plasma cells, with scarce...
18.
Yandamuri S, Filipek B, Obaid A, Lele N, Thurman J, Makhani N, et al.
JCI Insight
. 2023 Apr;
8(11).
PMID: 37097758
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an inflammatory demyelinating CNS condition characterized by the presence of MOG autoantibodies. We sought to investigate whether human MOG autoantibodies are capable...
19.
Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis
Masi G, Pham M, Karatz T, Oh S, Payne A, Nowak R, et al.
Ann Clin Transl Neurol
. 2023 Mar;
10(5):825-831.
PMID: 36924454
To compare the immunopathology of immune checkpoint inhibitor-induced myasthenia gravis (ICI-MG) and idiopathic MG, we profiled the respective AChR autoantibody pathogenic properties. Of three ICI-MG patients with AChR autoantibodies, only...
20.
Bennett J, Fujihara K, Kim H, Marignier R, OConnor K, Sergott R, et al.
Front Neurol
. 2023 Mar;
14:1114667.
PMID: 36873431
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that produces acute, unpredictable relapses causing cumulative neurological disability. Satralizumab, a humanized, monoclonal recycling...