Kevin C Flynn
Overview
Explore the profile of Kevin C Flynn including associated specialties, affiliations and a list of published articles.
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14
Citations
1364
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Recent Articles
1.
Lu X, Perr E, Naqvi T, Galitz D, Andersen M, Grabowski D, et al.
Cells
. 2024 Sep;
13(18.
PMID: 39329750
An essential aspect of harnessing the potential of pluripotent stem cells (PSCs) and their derivatives for regenerative medicine is the development of animal-free and chemically defined conditions for ex vivo...
2.
Tedeschi A, Dupraz S, Curcio M, Laskowski C, Schaffran B, Flynn K, et al.
Neuron
. 2019 Aug;
103(6):1073-1085.e6.
PMID: 31400829
Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating...
3.
Raju D, Schonauer S, Hamzeh H, Flynn K, Bradke F, Vom Dorp K, et al.
PLoS Genet
. 2015 Mar;
11(3):e1005063.
PMID: 25803043
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellular functions. Accumulation of the simple glycosphingolipid glucosylceramide results in life-threatening lipid storage-diseases or in male infertility. How...
4.
Ruschel J, Hellal F, Flynn K, Dupraz S, Elliott D, Tedeschi A, et al.
Science
. 2015 Mar;
348(6232):347-52.
PMID: 25765066
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the...
5.
Flynn K
Bioarchitecture
. 2013 Sep;
3(4):86-109.
PMID: 24002528
Neurons begin their life as simple spheres, but can ultimately assume an elaborate morphology with numerous, highly arborized dendrites, and long axons. This is achieved via an astounding developmental progression...
6.
Flynn K, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, et al.
Neuron
. 2012 Dec;
76(6):1091-107.
PMID: 23259946
Neurites are the characteristic structural element of neurons that will initiate brain connectivity and elaborate information. Early in development, neurons are spherical cells but this symmetry is broken through the...
7.
Hellal F, Hurtado A, Ruschel J, Flynn K, Laskowski C, Umlauf M, et al.
Science
. 2011 Jan;
331(6019):928-31.
PMID: 21273450
Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation...
8.
Marsick B, Flynn K, Santiago-Medina M, Bamburg J, Letourneau P
Dev Neurobiol
. 2010 May;
70(8):565-88.
PMID: 20506164
Proper neural circuitry requires that growth cones, motile tips of extending axons, respond to molecular guidance cues expressed in the developing organism. However, it is unclear how guidance cues modify...
9.
Tahirovic S, Hellal F, Neukirchen D, Hindges R, Garvalov B, Flynn K, et al.
J Neurosci
. 2010 May;
30(20):6930-43.
PMID: 20484635
Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is...
10.
Riedl J, Flynn K, Raducanu A, Gartner F, Beck G, Bosl M, et al.
Nat Methods
. 2010 Mar;
7(3):168-9.
PMID: 20195247
No abstract available.