Kevin Brown Chandler
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Explore the profile of Kevin Brown Chandler including associated specialties, affiliations and a list of published articles.
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20
Citations
444
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Recent Articles
11.
Azab E, Chandler K, Uda Y, Sun N, Hussein A, Shuwaikan R, et al.
FASEB J
. 2020 Jun;
34(8):10191-10211.
PMID: 32557809
Osteocytes, the bone cells embedded in the mineralized matrix, control bone modeling, and remodeling through direct contact with adjacent cells and via paracrine and endocrine factors that affect cells in...
12.
Fuzita F, Chandler K, Haserick J, Terra W, Ferreira C, Costello C
Comp Biochem Physiol B Biochem Mol Biol
. 2020 Jun;
246-247:110464.
PMID: 32553552
Spodoptera frugiperda is a widely distributed agricultural pest. It has previously been established that glycoproteins in the midgut microvillar membrane of insects are targets for toxins produced by different organisms...
13.
Chandler K, Alamoud K, Stahl V, Nguyen B, Kartha V, Bais M, et al.
Mol Omics
. 2020 Mar;
16(3):195-209.
PMID: 32203567
Epidermal growth factor receptor (EGFR) is a major driver of head and neck cancer, a devastating malignancy with a major sub-site in the oral cavity manifesting as oral squamous cell...
14.
Chandler K, Leon D, Kuang J, Meyer R, Rahimi N, Costello C
J Biol Chem
. 2019 Jul;
294(35):13117-13130.
PMID: 31308178
The tumor microenvironment and proinflammatory signals significantly alter glycosylation of cell-surface proteins on endothelial cells. By altering the -glycosylation machinery in the endoplasmic reticulum and Golgi, proinflammatory cytokines promote the...
15.
Chandler K, Costello C, Rahimi N
Cells
. 2019 Jun;
8(6).
PMID: 31195728
Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression...
16.
Chandler K, Mehta N, Leon D, Suscovich T, Alter G, Costello C
Mol Cell Proteomics
. 2019 Jan;
18(4):686-703.
PMID: 30659065
Antibodies are critical glycoproteins that bridge the innate and adaptive immune systems to provide protection against infection. The isotype/subclass of the antibody, the co-translational -glycosylation on the CH2 domain, and...
17.
Chandler K, Leon D, Meyer R, Rahimi N, Costello C
J Proteome Res
. 2016 Dec;
16(2):677-688.
PMID: 27966990
Vascular endothelial growth factor receptor-2 (VEGFR-2) is an important receptor tyrosine kinase (RTK) that plays critical roles in both physiologic and pathologic angiogenesis. The extracellular domain of VEGFR-2 is composed...
18.
Chandler K, Costello C
Electrophoresis
. 2016 Feb;
37(11):1407-19.
PMID: 26872045
Membrane proteins mediate cell-cell interactions and adhesion, the transfer of ions and metabolites, and the transmission of signals from the extracellular environment to the cell interior. The extracellular domains of...
19.
Chandler K, Brnakova Z, Sanda M, Wang S, Stalnaker S, Bridger R, et al.
J Proteome Res
. 2014 Jun;
13(7):3314-29.
PMID: 24884609
Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is a 120 kDa acute-phase glycoprotein produced primarily in the liver, secreted into the blood, and identified in serum. ITIH4 is involved in liver...
20.
Chandler K, Pompach P, Goldman R, Edwards N
J Proteome Res
. 2013 Jul;
12(8):3652-66.
PMID: 23829323
Glycosylation is a common protein modification with a significant role in many vital cellular processes and human diseases, making the characterization of protein-attached glycan structures important for understanding cell biology...