Kevin Brown Chandler
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Explore the profile of Kevin Brown Chandler including associated specialties, affiliations and a list of published articles.
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20
Citations
444
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Recent Articles
1.
Miller S, Jeanne Dit Fouque K, Mebel A, Chandler K, Fernandez-Lima F
J Phys Chem B
. 2024 Sep;
128(37):8869-8877.
PMID: 39226480
Fucosylated carbohydrate antigens play critical roles in physiology and pathology with function linked to their structural details. However, the separation and structural characterization of isomeric fucosylated epitopes remain challenging analytically....
2.
Marrero Roche D, Chandler K
J Mass Spectrom
. 2024 Aug;
59(9):e5083.
PMID: 39162140
Protein glycosylation is the co- and/or post-translational modification of proteins with oligosaccharides (glycans). This process is not template based and can introduce a heterogeneous set of glycan modifications onto substrate...
3.
Abdoollah Z, Marrero Roche D, Pavan C, Moore E, Chandler K
J Proteome Res
. 2024 Jul;
23(8):3469-3483.
PMID: 39007905
Fcγ-receptors (FcγRs) including FcγRII (CD32) gene family members are expressed on leukocytes, bind the crystallizable fragment (Fc) region of immunoglobulin G (IgG), and bridge humoral and cellular immunity. FcγRIIA and...
4.
Pavan C, Abdoollah Z, Marrero Roche D, Ryan H, Moore E, Chandler K
J Proteome Res
. 2024 Feb;
23(3):1088-1101.
PMID: 38363599
Fc γ-receptors (FcγRs) on leukocytes bind immunoglobulin G (IgG) immune complexes to mediate effector functions. Dysregulation of FcγR-mediated processes contributes to multiple inflammatory diseases, including rheumatoid arthritis, lupus, and immune...
5.
Chandler K, Pavan C, Cotto Aparicio H, Sackstein R
J Proteome Res
. 2023 Mar;
22(4):1231-1244.
PMID: 36971183
Mucin-domain glycoproteins expressed on cancer cell surfaces play central roles in cell adhesion, cancer progression, stem cell renewal, and immune evasion. Despite abundant evidence that mucin-domain glycoproteins are critical to...
6.
Chandler K, Marrero Roche D, Sackstein R
Anal Bioanal Chem
. 2022 Nov;
415(3):379-390.
PMID: 36401639
Bottom-up nLC-MS/MS-based glycoprotein mass spectrometry workflows rely on the generation of a mixture of non-glycosylated and glycosylated peptides via proteolysis of glycoproteins. Such methods are challenged by suppression of hydrophilic...
7.
Montesino B, Steenackers A, Lozano J, Young G, Hu N, Sackstein R, et al.
Glycobiology
. 2021 Dec;
32(5):441-455.
PMID: 34939118
Head and neck cancer is the seventh most common cancer in the world, and most cases manifest as head and neck squamous cell carcinoma. Despite the prominent role of fucosylated...
8.
Rahimi N, Ho R, Chandler K, De La Cena K, Amraei R, Mitchel A, et al.
J Biomed Sci
. 2021 Sep;
28(1):61.
PMID: 34503512
Background: The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell-cell adhesion, cell proliferation and cell cycle....
9.
Amraei R, Yin W, Napoleon M, Suder E, Berrigan J, Zhao Q, et al.
ACS Cent Sci
. 2021 Aug;
7(7):1156-1165.
PMID: 34341769
As the COVID-19 pandemic continues to spread, investigating the processes underlying the interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the identification of CD209L/L-SIGN and...
10.
Amraei R, Yin W, Napoleon M, Suder E, Berrigan J, Zhao Q, et al.
bioRxiv
. 2020 Jul;
PMID: 32607506
As the COVID-19 pandemic continues to spread, investigating the processes underlying the interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the identification of CD209L/L-SIGN and...