Kevin Bellofatto
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Explore the profile of Kevin Bellofatto including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Honarpisheh M, Lei Y, Follenzi A, Cucci A, Olgasi C, Berishvili E, et al.
Cells
. 2025 Mar;
14(5).
PMID: 40072094
The engraftment of transplanted islets depends on the rapid establishment of a novel vascular network. The present study evaluated the effects of cord blood-derived blood outgrowth endothelial cells (BOECs) on...
2.
Cottet-Dumoulin D, Fonseca L, Bignard J, Hanna R, Parnaud G, Lebreton F, et al.
Am J Physiol Endocrinol Metab
. 2023 May;
325(1):E21-E31.
PMID: 37257886
Obesity and lipid metabolism dysregulation are often associated with insulin resistance, and can lead to type 2 diabetes. However, mechanisms linking insulin resistance, high levels of plasma free fatty acids...
3.
Cottet-Dumoulin D, Perrier Q, Lavallard V, Matthey-Doret D, Fonseca L, Bignard J, et al.
J Endocrinol
. 2023 May;
258(2).
PMID: 37256642
Cell protein biosynthesis is regulated by different factors, but implication of intercellular contacts on alpha and beta cell protein biosyntheses activity has not been yet investigated. Islet cell biosynthetic activity...
4.
Berney T, Wassmer C, Lebreton F, Bellofatto K, Fonseca L, Bignard J, et al.
Presse Med
. 2022 Oct;
51(4):104139.
PMID: 36202182
Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing beta cells in the pancreas. When type 1 diabetes develops into severe secondary complications, in particular end-stage...
5.
Wassmer C, Lebreton F, Bellofatto K, Perez L, Cottet-Dumoulin D, Andres A, et al.
Transpl Int
. 2022 Feb;
35:10214.
PMID: 35185372
Lack of rapid revascularization and inflammatory attacks at the site of transplantation contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet transplantation. In order to overcome these...
6.
Lebreton F, Hanna R, Wassmer C, Bellofatto K, Perez L, Othenin-Girard V, et al.
Stem Cell Rev Rep
. 2021 Oct;
18(1):346-359.
PMID: 34613550
Inhibiting pro-inflammatory cytokine activity can reverse inflammation mediated dysfunction of islet grafts. Human amniotic epithelial cells (hAECs) possess regenerative, immunomodulatory and anti-inflammatory properties. We hypothesized that hAECs could protect islets...
7.
Perrier Q, Lavallard V, Pernin N, Wassmer C, Cottet-Dumoulin D, Lebreton F, et al.
Islets
. 2021 Feb;
13(1-2):1-9.
PMID: 33616002
This study aimed to assess the global mapping risk of human islet isolation, using a failure mode and effect analysis (FMEA), and highlight the impact of quality assurance procedures on...
8.
Cottet-Dumoulin D, Lavallard V, Lebreton F, Wassmer C, Bellofatto K, Parnaud G, et al.
Endocrinology
. 2020 Dec;
162(3).
PMID: 33367617
A correct biosynthetic activity is thought to be essential for the long-term function and survival of islet cells in culture and possibly also after islet transplantation. Compared to the secretory...
9.
Lebreton F, Lavallard V, Bellofatto K, Bonnet R, Wassmer C, Perez L, et al.
Nat Commun
. 2020 Oct;
11(1):5159.
PMID: 33037230
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
10.
Wassmer C, Perrier Q, Combescure C, Pernin N, Parnaud G, Cottet-Dumoulin D, et al.
Am J Transplant
. 2020 Sep;
21(4):1493-1502.
PMID: 32986297
Many variables impact islet isolation, including pancreas ischemia time. The ischemia time upper limit that should be respected to avoid a negative impact on the isolation outcome is not well...