Kevin B Teuscher
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Explore the profile of Kevin B Teuscher including associated specialties, affiliations and a list of published articles.
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11
Citations
108
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Recent Articles
1.
Meyer C, Smith B, Wang J, Teuscher K, Grieb B, Howard G, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2408889121.
PMID: 39167600
WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin...
2.
Teuscher K, Mills J, Tian J, Han C, Meyers K, Sai J, et al.
J Med Chem
. 2023 Dec;
66(24):16783-16806.
PMID: 38085679
The chromatin-associated protein WDR5 (WD repeat domain 5) is an essential cofactor for MYC and a conserved regulator of ribosome protein gene transcription. It is also a high-profile target for...
3.
Teuscher K, Chowdhury S, Meyers K, Tian J, Sai J, Van Meveren M, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2211297120.
PMID: 36574664
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of...
4.
Teuscher K, Meyers K, Wei Q, Mills J, Tian J, Alvarado J, et al.
J Med Chem
. 2022 Apr;
65(8):6287-6312.
PMID: 35436124
WD repeat domain 5 (WDR5) is a nuclear scaffolding protein that forms many biologically important multiprotein complexes. The WIN site of WDR5 represents a promising pharmacological target in a variety...
5.
Rietz T, Teuscher K, Mills J, Gogliotti R, Lepovitz L, Scaggs W, et al.
J Med Chem
. 2021 Oct;
64(19):14757-14772.
PMID: 34597046
T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3; HAVCR2) has emerged as an attractive immune checkpoint target for cancer immunotherapy. TIM-3 is a negative regulator of the systemic immune response...
6.
Li Z, Zhang M, Teuscher K, Ji H
J Med Chem
. 2021 Jul;
64(15):11195-11218.
PMID: 34270257
Structure-based design and optimization were performed to develop small-molecule β-catenin/B-cell lymphoma 9 (BCL9) inhibitors and improve their inhibitory activities. Compound with a novel 1-benzoyl 4-phenoxypiperidine scaffold was discovered to disrupt...
7.
Tian J, Teuscher K, Aho E, Alvarado J, Mills J, Meyers K, et al.
J Med Chem
. 2019 Dec;
63(2):656-675.
PMID: 31858797
WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple chromatin-centric processes. Overexpression of WDR5 correlates with a poor clinical...
8.
Zhang Y, Teuscher K, Ji H
Chem Sci
. 2018 Jun;
7(3):2111-2118.
PMID: 29899938
A photoredox reaction for cross-dehydrogenative coupling (CDC) was developed to C-arylate amides (α to nitrogen) and ethers using a variety of five- and six-membered electron-deficient heteroarenes. A unique decomposition mechanism...
9.
Teuscher K, Zhang M, Ji H
J Med Chem
. 2016 Dec;
60(1):157-169.
PMID: 27935314
The determination of the cellular bioavailability of small-molecule inhibitors is a critical step for interpreting cell-based data and guiding inhibitor optimization. Herein, a HPLC-MS based protocol was developed to determine...
10.
Wisniewski J, Yin J, Teuscher K, Zhang M, Ji H
ACS Med Chem Lett
. 2016 May;
7(5):508-13.
PMID: 27190602
A small-molecule inhibitor with a 1,4-dibenzoylpiperazine scaffold was designed to match the critical binding elements in the β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction interface. Inhibitor optimization led to a potent...