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Kevin A McDonnell

Explore the profile of Kevin A McDonnell including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 74
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Recent Articles
1.
Breathnach R, McDonnell K, Chebbi A, Callanan J, Dowling D
Biointerphases . 2018 Oct; 13(5):051002. PMID: 30326703
Chronic nonhealing wounds, particularly those complicated by multidrug resistant infections, represent a major health and economic challenge. Plasma treatment promotes wound repair due to its antimicrobial, angiogenic, and cell modulating...
2.
Scully S, Minden Z, Mukerji R, Andrianova E, Kaberna J, Lentini S, et al.
ACS Med Chem Lett . 2017 Feb; 8(2):196-200. PMID: 28197311
Several monoclonal antibodies and inhibitors targeting CD38, an ectoenzyme overexpressed on malignant plasma cells, have previously been discovered. Herein, we expand structure-activity relationships of reported small-molecule thiazoloquinolinones and show that...
3.
Sharkey M, Chebbi A, McDonnell K, Staunton C, Dowling D
Biointerphases . 2015 Apr; 10(2):029507. PMID: 25850415
The focus of this research was first to determine the influence of the atmospheric plasma drive frequency on the generation of atomic oxygen species and its correlation with the reduction...
4.
Mezo A, McDonnell K, Low S, Song J, Reidy T, Lu Q, et al.
Bioconjug Chem . 2012 Jan; 23(3):518-26. PMID: 22263969
Atrial natriuretic peptide (ANP) may be a useful molecule for the treatment of cardiovascular diseases due to its potent natriuretic effects. In an effort to prolong the short in vivo...
5.
McDonnell K, Low S, Hoehn T, Donnelly R, Palmieri H, Fraley C, et al.
J Med Chem . 2010 Jan; 53(4):1587-96. PMID: 20092334
The neonatal Fc receptor, FcRn, regulates the half-life of IgG in vivo and may be a target in the treatment of autoimmune disease. Monomeric peptide antagonists of the human IgG-human...
6.
Mezo A, McDonnell K, Castro A, Fraley C
Bioorg Med Chem . 2008 May; 16(12):6394-405. PMID: 18501614
A family of five peptides was previously discovered by phage display techniques that binds to the human neonatal Fc receptor (FcRn) and inhibits the human IgG:human FcRn protein-protein interaction [Proc....
7.
Mezo A, McDonnell K, Tan Hehir C, Low S, Palombella V, Stattel J, et al.
Proc Natl Acad Sci U S A . 2008 Feb; 105(7):2337-42. PMID: 18272495
The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-lives in vivo by protecting them from intracellular catabolism and then returning them to the extracellular space. Other...
8.
McDonnell K, Imperiali B
J Am Chem Soc . 2002 Jan; 124(3):428-33. PMID: 11792213
The role of a single glycine hinge residue in the structure of BBAT1, a beta(beta)(alpha) peptide that forms a discrete homotrimeric structure in solution, was evaluated with 11 new peptide...