Keun-A Chang
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Explore the profile of Keun-A Chang including associated specialties, affiliations and a list of published articles.
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74
Citations
1398
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Recent Articles
1.
Kim Y, Ha T, Lee M, Chang K
Int J Biol Sci
. 2025 Feb;
21(3):1014-1031.
PMID: 39897039
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs) formed from hyperphosphorylated Tau, and widespread neuronal loss. The autophagy-lysosomal pathway plays a crucial role...
2.
Ko G, Kim J, Hong Y, Jeon Y, Baek H, Lee D, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859214
Ischemic stroke, caused by blocked cerebral blood flow, requires prompt intervention to prevent severe motor and cognitive impairments. Despite extensive drug development efforts, the failure rate of clinical trials remains...
3.
Hong Y, Ko G, Jeon Y, Baek H, Lee J, Lee D, et al.
Cells
. 2025 Jan;
14(2.
PMID: 39851546
Stroke affects over 12 million people annually, leading to high mortality, long-term disability, and substantial healthcare costs. Although East Asian herbal medicines are widely used for stroke treatment, the pathways...
4.
Md Samsuzzaman , Hong S, Lee J, Park H, Chang K, Kim H, et al.
Biol Res
. 2024 Nov;
57(1):87.
PMID: 39574138
Background: Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia...
5.
Jung S, Jang W, Beom B, Won J, Jeong J, Choi Y, et al.
Polymers (Basel)
. 2024 Nov;
16(21).
PMID: 39518193
High-frequency noise exceeding 1 kHz has emerged as a pressing public health issue in industrial and occupational settings. In response to this challenge, the present study explores the development of...
6.
Ha T, Kim J, Kim Y, Park S, Chang K
Pharmacol Res
. 2024 Sep;
209:107432.
PMID: 39313081
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) and accumulation of intracellular α-synuclein (ɑ-syn) aggregates known as Lewy bodies and Lewy...
7.
Kim K, Shin K, Chang K
Int J Mol Sci
. 2024 May;
25(10.
PMID: 38791346
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Given its prevalence, reliable biomarkers for early diagnosis are required. Exosomal proteins within extracellular nanovesicles are promising candidates for...
8.
Sharma H, Chang K, Hulme J, An S
Cells
. 2023 Oct;
12(20).
PMID: 37887303
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a complex multi-stage disease that currently afflicts over 50 million people worldwide. Unfortunately, previous therapeutic strategies developed...
9.
Kim K, Shin K, Chang K
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762207
Major depressive disorder (MDD) is a highly prevalent psychiatric condition affecting an estimated 280 million individuals globally. Despite the occurrence of suicidal behaviors across various psychiatric conditions, MDD is distinctly...
10.
Seo H, Ha T, Ko G, Jang A, Choi J, Lee D, et al.
Cells
. 2023 Sep;
12(17).
PMID: 37681864
Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological...