Keshav Motwani
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Explore the profile of Keshav Motwani including associated specialties, affiliations and a list of published articles.
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9
Citations
134
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Recent Articles
1.
Kruper J, Hagen M, Rheault F, Crane I, Gilmore A, Narayan M, et al.
Front Neurosci
. 2024 Jun;
18:1389680.
PMID: 38933816
Introduction: The Human Connectome Project (HCP) has become a keystone dataset in human neuroscience, with a plethora of important applications in advancing brain imaging methods and an understanding of the...
2.
Molstad A, Motwani K
Biometrics
. 2023 Oct;
79(4):3485-3496.
PMID: 37798600
In many categorical response regression applications, the response categories admit a multiresolution structure. That is, subsets of the response categories may naturally be combined into coarser response categories. In such...
3.
Shapiro M, Dong X, Perry D, McNichols J, Thirawatananond P, Posgai A, et al.
JCI Insight
. 2023 Jul;
8(17).
PMID: 37498686
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in...
4.
Pavlovic M, Scheffer L, Motwani K, Kanduri C, Kompova R, Vazov N, et al.
Nat Mach Intell
. 2023 Jul;
3(11):936-944.
PMID: 37396030
Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as they record past and ongoing adaptive immune responses. The capacity of machine learning (ML) to identify complex discriminative...
5.
Kanduri C, Pavlovic M, Scheffer L, Motwani K, Chernigovskaya M, Greiff V, et al.
Gigascience
. 2022 May;
11.
PMID: 35639633
Background: Machine learning (ML) methodology development for the classification of immune states in adaptive immune receptor repertoires (AIRRs) has seen a recent surge of interest. However, so far, there does...
6.
Linsley P, Barahmand-Pour-Whitman F, Balmas E, DeBerg H, Flynn K, Hu A, et al.
JCI Insight
. 2021 Nov;
6(22).
PMID: 34806648
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to...
7.
Motwani K, Peters L, Vliegen W, El-Sayed A, Seay H, Lopez M, et al.
Front Immunol
. 2020 May;
11:611.
PMID: 32351504
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell...
8.
Ihantola E, Ilmonen H, Kailaanmaki A, Rytkonen-Nissinen M, Azam A, Maillere B, et al.
J Immunol
. 2020 Apr;
204(9):2349-2359.
PMID: 32229538
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin-producing β cells within the pancreas are destroyed. Identification of target Ags and epitopes of the β...
9.
Khosravi-Maharlooei M, Obradovic A, Misra A, Motwani K, Holzl M, Seay H, et al.
J Clin Invest
. 2019 Mar;
129(6):2446-2462.
PMID: 30920391
We investigated human T-cell repertoire formation using high throughput TCRβ CDR3 sequencing in immunodeficient mice receiving human hematopoietic stem cells (HSCs) and human thymus grafts. Replicate humanized mice generated diverse...