Kerstin N Timm
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Explore the profile of Kerstin N Timm including associated specialties, affiliations and a list of published articles.
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23
Citations
308
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Recent Articles
1.
Malik M, Guo F, Asif-Malik A, Eftychidis V, Barkas N, Eliseeva E, et al.
Nat Metab
. 2024 Oct;
6(11):2100-2117.
PMID: 39468205
Identifying initial triggering events in neurodegenerative disorders is critical to developing preventive therapies. In Huntington's disease (HD), hyperdopaminergia-probably triggered by the dysfunction of the most affected neurons, indirect pathway spiny...
2.
Choksey A, Carter R, Thackray B, Ball V, Kennedy B, Ha L, et al.
J Mol Cell Cardiol
. 2024 Apr;
191:12-22.
PMID: 38643934
Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects, leading to heart failure (HF). Impaired mitochondrial function is thought to be key factor driving...
3.
Timm K, Ball V, Miller J, Savic D, West J, Griffin J, et al.
Front Physiol
. 2022 Jan;
12:782745.
PMID: 35069242
Doxorubicin (DOX) is a successful chemotherapeutic widely used for the treatment of a range of cancers. However, DOX can have serious side-effects, with cardiotoxicity and hepatotoxicity being the most common...
4.
Cancer Therapy-Induced Cardiotoxicity-A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy
Choksey A, Timm K
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008867
Long-term cardiovascular complications of cancer therapy are becoming ever more prevalent due to increased numbers of cancer survivors. Cancer therapy-induced cardiotoxicity (CTIC) is an incompletely understood consequence of various chemotherapies,...
5.
Savic D, Ball V, Curtis M, Sousa Fialho M, Timm K, Hauton D, et al.
Metabolites
. 2021 Apr;
11(3).
PMID: 33806953
The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to the metabolic dysfunction in diabetes may be abnormal handling...
6.
Miller J, Valkovic L, Kerr M, Timm K, Watson W, Lau J, et al.
Magn Reson Med
. 2021 Feb;
85(6):2978-2991.
PMID: 33538063
Purpose: Phosphorus saturation-transfer experiments can quantify metabolic fluxes noninvasively. Typically, the forward flux through the creatine kinase reaction is investigated by observing the decrease in phosphocreatine (PCr) after saturation of...
7.
Savic D, Ball V, Holzner L, Hauton D, Timm K, Curtis M, et al.
NMR Biomed
. 2021 Jan;
34(4):e4471.
PMID: 33458907
The diabetic heart has a decreased ability to metabolize glucose. The anti-ischemic drug meldonium may provide a route to counteract this by reducing l-carnitine levels, resulting in improved cardiac glucose...
8.
Timm K, Perera C, Ball V, Henry J, Miller J, Kerr M, et al.
Commun Biol
. 2020 Nov;
3(1):692.
PMID: 33214680
Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers...
9.
Watson W, Timm K, Lewis A, Miller J, Emmanuel Y, Clarke K, et al.
FASEB J
. 2020 Sep;
34(11):14878-14891.
PMID: 32954525
Nicotinic acid receptor agonists have previously been shown to cause acute reductions in cardiac contractility. We sought to uncover the changes in cardiac metabolism underlying these alterations in function. In...
10.
Marco-Rius I, Wright A, Hu D, Savic D, Miller J, Timm K, et al.
MAGMA
. 2020 Sep;
34(1):49-56.
PMID: 32910316
Objectives: To enhance detection of the products of hyperpolarized [2-C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-C]DHAc emerged as a promising substrate to...