Keren E Shapira
Overview
Explore the profile of Keren E Shapira including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
138
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0
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Recent Articles
1.
Szilagyi S, Amsalem-Zafran A, Shapira K, Ehrlich M, Henis Y
BMC Biol
. 2022 Feb;
20(1):50.
PMID: 35177083
Background: Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases. They signal to distinct Smad branches; activins signal mainly to...
2.
Shapira K, Shapira G, Schmukler E, Pasmanik-Chor M, Shomron N, Pinkas-Kramarski R, et al.
Cell Death Discov
. 2021 Oct;
7(1):320.
PMID: 34716312
Perturbations to cellular homeostasis, including reduction of the cholesterol level, induce autophagy, a self-digestion process of cellular constituents through an autophagosomal-lysosomal pathway. In accord with its function as a membrane...
3.
Shapira K, Ehrlich M, Henis Y
Mol Biol Cell
. 2018 Aug;
29(20):2494-2507.
PMID: 30091670
Transforming growth factor-β (TGF-β) plays critical roles in numerous physiological and pathological responses. Cholesterol, a major plasma membrane component, can have pronounced effects on signaling responses. Cells continually monitor cholesterol...
4.
Amsalem A, Marom B, Shapira K, Hirschhorn T, Preisler L, Paarmann P, et al.
Mol Biol Cell
. 2016 Jan;
27(4):716-30.
PMID: 26739752
The expression and function of transforming growth factor-β superfamily receptors are regulated by multiple molecular mechanisms. The type II BMP receptor (BMPRII) is expressed as two alternatively spliced forms, a...
5.
Shapira K, Hirschhorn T, Barzilay L, Smorodinsky N, Henis Y, Ehrlich M
Mol Biol Cell
. 2014 Mar;
25(10):1620-8.
PMID: 24648493
Transforming growth factor-β (TGF-β) ligands activate Smad-mediated and noncanonical signaling pathways in a cell context-dependent manner. Localization of signaling receptors to distinct membrane domains is a potential source of signaling...
6.
Shapira K, Gross A, Ehrlich M, Henis Y
J Biol Chem
. 2012 Jun;
287(32):26876-89.
PMID: 22707720
The roles of transforming growth factor-β (TGF-β) receptor endocytosis in signaling have been investigated in numerous studies, mainly through the use of endocytosis inhibitory treatments, yielding conflicting results. Two potential...
7.
Rechtman M, Nakaryakov A, Shapira K, Ehrlich M, Henis Y
J Biol Chem
. 2009 Jan;
284(12):7843-52.
PMID: 19147499
Transforming growth factor-beta (TGF-beta) binds to and signals via two serine-threonine kinase receptors, type I (TbetaRI) and type II (TbetaRII). The oligomerization of TGF-beta receptors modulates ligand binding and receptor...
8.
Kalo E, Buganim Y, Shapira K, Besserglick H, Goldfinger N, Weisz L, et al.
Mol Cell Biol
. 2007 Sep;
27(23):8228-42.
PMID: 17875924
Both transforming growth factor beta (TGF-beta) and p53 have been shown to control normal cell growth. Acquired mutations either in the TGF-beta signaling pathway or in the p53 protein were...
9.
Murphy S, Shapira K, Henis Y, Leof E
Mol Biol Cell
. 2007 Jul;
18(10):3788-99.
PMID: 17634290
Transforming growth factor (TGF)-beta receptors stimulate diverse signaling processes that control a wide range of biological responses. In polarized epithelia, the TGFbeta type II receptor (T2R) is localized at the...