Keren Bahar Halpern
Overview
Explore the profile of Keren Bahar Halpern including associated specialties, affiliations and a list of published articles.
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33
Citations
2761
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Recent Articles
1.
Novoselsky R, Harnik Y, Yakubovsky O, Katina C, Levin Y, Bahar Halpern K, et al.
PLoS Biol
. 2024 Dec;
22(12):e3002942.
PMID: 39621797
The intestinal epithelium is a polarized monolayer of cells, with an apical side facing the lumen and a basal side facing the blood stream. In mice, both proteins and mRNAs...
2.
Harnik Y, Yakubovsky O, Hoefflin R, Novoselsky R, Bahar Halpern K, Barkai T, et al.
Nature
. 2024 Aug;
632(8027):1101-1109.
PMID: 39112711
The mouse small intestine shows profound variability in gene expression along the crypt-villus axis. Whether similar spatial heterogeneity exists in the adult human gut remains unclear. Here we use spatial...
3.
Bahar Halpern K, Korem Kohanim Y, Biram A, Harnik Y, Egozi A, Yakubovsky O, et al.
Nat Metab
. 2023 Oct;
5(11):1858-1869.
PMID: 37857731
The intestinal epithelium is replaced every few days. Enterocytes are shed into the gut lumen predominantly from the tips of villi and have been believed to rapidly die upon their...
4.
Dan S, Ungar B, Ben-Moshe S, Bahar Halpern K, Yavzori M, Fudim E, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Feb;
16(1):1-15.
PMID: 36791991
Background & Aims: Noninvasive modalities for assessing active endoscopic and histologic inflammation in Crohn's disease and ulcerative colitis patients are critically needed. Fecal wash host shed-cell transcriptomics has been shown...
5.
Afriat A, Zuzarte-Luis V, Bahar Halpern K, Buchauer L, Marques S, Chora A, et al.
Nature
. 2022 Nov;
611(7936):563-569.
PMID: 36352220
Malaria infection involves an obligatory, yet clinically silent liver stage. Hepatocytes operate in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along the lobule axis, but the effects of...
6.
Ben-Moshe S, Veg T, Manco R, Dan S, Papinutti D, Lifshitz A, et al.
Cell Stem Cell
. 2022 Jun;
29(6):973-989.e10.
PMID: 35659879
The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell approaches are necessary to study this process, given the spatial heterogeneity of liver cell types. Here,...
7.
Ungar B, Yavzori M, Fudim E, Picard O, Kopylov U, Eliakim R, et al.
Gut
. 2022 Jan;
71(10).
PMID: 35046090
Background: Colonoscopy is the gold standard for evaluation of inflammation in inflammatory bowel diseases (IBDs), yet entails cumbersome preparations and risks of injury. Existing non-invasive prognostic tools are limited in...
8.
Egozi A, Llivichuzhca-Loja D, McCourt B, Bahar Halpern K, Farack L, An X, et al.
Nat Med
. 2021 Dec;
27(12):2104-2107.
PMID: 34887578
Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and...
9.
Cohen N, Massalha H, Ben-Moshe S, Egozi A, Rozenberg M, Bahar Halpern K, et al.
PLoS Biol
. 2021 Oct;
19(10):e3001214.
PMID: 34634036
The intestine is lined with isolated lymphoid follicles (ILFs) that facilitate sampling of luminal antigens to elicit immune responses. Technical challenges related to the scarcity and small sizes of ILFs...
10.
Manco R, Averbukh I, Porat Z, Bahar Halpern K, Amit I, Itzkovitz S
Nat Commun
. 2021 May;
12(1):3074.
PMID: 34031373
Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types, since their mRNA contents...