Kenneth MacLennan
Overview
Explore the profile of Kenneth MacLennan including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
224
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0
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Recent Articles
1.
Wood H, Daly C, Chalkley R, Senguven B, Ross L, Egan P, et al.
Genome Med
. 2017 Jun;
9(1):53.
PMID: 28592326
Background: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver...
2.
Wood H, Conway C, Daly C, Chalkley R, Berri S, Senguven B, et al.
J Pathol
. 2015 Jun;
237(3):296-306.
PMID: 26096211
The study of the relationships between pre-cancer and cancer and identification of early driver mutations is becoming increasingly important as the value of molecular markers of early disease and personalised...
3.
Samman M, Wood H, Conway C, Stead L, Daly C, Chalkley R, et al.
Int J Cancer
. 2015 May;
137(10):2364-73.
PMID: 26014678
Verrucous carcinoma of the oral cavity (OVC) is considered a subtype of classical oral squamous cell carcinoma (OSCC). Diagnosis is problematic, and additional biomarkers are needed to better stratify patients....
4.
Sethi N, MacLennan K, Wood H, Rabbitts P
Head Neck
. 2015 Apr;
38 Suppl 1:E2395-402.
PMID: 25900457
Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to next-generation sequencing (NGS)...
5.
Samman M, Wood H, Conway C, Berri S, Pentenero M, Gandolfo S, et al.
Oral Surg Oral Med Oral Pathol Oral Radiol
. 2014 Jun;
118(1):117-125.e1.
PMID: 24908602
Objective: The etiology of oral verrucous carcinoma is unknown, and human papillomavirus 'involvement' remains contentious. The uncertainty can be attributed to varied detection procedures and difficulties in defining 'gold-standard' histologic...
6.
Chambers J, Tanaka T, Brend T, Ali H, Geisler N, Khazin L, et al.
Cancer Res
. 2014 Jan;
74(5):1588-97.
PMID: 24419086
The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been described...
7.
Nankivell P, Williams H, Webster K, Pearson D, High A, MacLennan K, et al.
J Oral Pathol Med
. 2013 Dec;
43(4):245-9.
PMID: 24372672
Background: Human papilloma virus is a risk factor for oropharyngeal cancer. Evidence for a similar aetiological role in the development of oral dysplasia or its transformation to oral cancer is...
8.
Charaklias N, Makura Z, Mihangel S, MacLennan K, Kanatas A
Ear Nose Throat J
. 2013 Dec;
92(12):566.
PMID: 24366705
No abstract available.
9.
Conway C, Chalkley R, High A, MacLennan K, Berri S, Chengot P, et al.
J Mol Diagn
. 2012 Jan;
14(2):104-11.
PMID: 22240447
Human papillomavirus (HPV) infection in cases of squamous cell carcinoma of the oropharynx is a powerful predictive and prognostic biomarker. We describe how the use of next-generation sequencing can provide...
10.
Belvedere O, Berri S, Chalkley R, Conway C, Barbone F, Pisa F, et al.
Genomics
. 2011 Nov;
99(1):18-24.
PMID: 22050995
Squamous cell carcinoma of the lung is remarkable for the extent to which the same chromosomal abnormalities are detected in individual tumours. We have used next generation sequencing at low...