Kenneth K Teng
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Explore the profile of Kenneth K Teng including associated specialties, affiliations and a list of published articles.
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12
Citations
1961
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Recent Articles
1.
Greenwood S, Montroull L, Volosin M, Scharfman H, Teng K, Light M, et al.
eNeuro
. 2018 Jan;
5(1).
PMID: 29349290
Neurotrophins play critical roles in the survival, maintenance and death of neurons. In particular, proneurotrophins have been shown to mediate cell death following brain injury induced by status epilepticus (SE)...
2.
Tauris J, Gustafsen C, Ilso Christensen E, Jansen P, Nykjaer A, Nyengaard J, et al.
Eur J Neurosci
. 2011 Jan;
33(4):622-31.
PMID: 21261755
The precursor of the neurotrophin (NT) nerve growth factor (NGF) (proNGF) serves physiological functions distinct from its mature counterpart as it induces neuronal apoptosis through activation of a p75 NT...
3.
Teng K, Felice S, Kim T, Hempstead B
Dev Neurobiol
. 2010 Feb;
70(5):350-9.
PMID: 20186707
Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which undergo proteolytic cleavage to yield mature forms. Although the functions of the mature neurotrophins have been well established during neural development...
4.
Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng K, et al.
J Mol Biol
. 2009 Dec;
396(4):967-84.
PMID: 20036257
Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive precursor...
5.
Yano H, Torkin R, Martin L, Chao M, Teng K
J Neurosci
. 2009 Nov;
29(47):14790-802.
PMID: 19940174
Although mature neurotrophins are well described trophic factors that elicit retrograde survival signaling, the precursor forms of neurotrophins (i.e., proneurotrophins) can function as high-affinity apoptotic ligands for selected neural populations....
6.
Arevalo J, Pereira D, Yano H, Teng K, Chao M
J Biol Chem
. 2005 Nov;
281(2):1001-7.
PMID: 16284401
Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, activate Trk receptor tyrosine kinases through receptor dimerization at the cell surface followed by autophosphorylation and recruitment of intracellular signaling...
7.
Teng H, Teng K, Lee R, Wright S, Tevar S, Almeida R, et al.
J Neurosci
. 2005 Jun;
25(22):5455-63.
PMID: 15930396
Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal survival, differentiation, and synaptic modulation mediated by the TrkB receptor tyrosine kinase. Developmentally regulated death signaling by BDNF...
8.
Klein M, Hempstead B, Teng K
J Neurobiol
. 2005 Feb;
63(2):159-71.
PMID: 15702476
Neurotrophins exert many of their biological effects via the Trk receptor tyrosine kinases and require the regulated activation of distinct transcriptional and post-translational cellular events. Here we provide evidence for...
9.
Pang P, Teng H, Zaitsev E, Woo N, Sakata K, Zhen S, et al.
Science
. 2004 Oct;
306(5695):487-91.
PMID: 15486301
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in...
10.
Arevalo J, Yano H, Teng K, Chao M
EMBO J
. 2004 May;
23(12):2358-68.
PMID: 15167895
A major question in cell biology is how molecular specificity is achieved by different growth factor receptors that activate apparently identical signaling events. For the neurotrophin family, a distinguishing feature...